Iron is an essential element in multiple biochemical pathways in humans and pathogens. As
part of the innate immune response in local infection, iron availability is restricted locally in …

The exploration into the strategies for the prevention and treatment of cancer is far from
complete. Apart from humans, cancer has gained considerable importance in animals …

Abstract Bovine herpesvirus 1 (BoHV-1) requires an iron-replete cell host to replicate
efficiently. BoHV-1 infection provokes an increase in ferritin levels and a decrease of …

An enteric virus named Canine parvovirus type 2 (CPV-2) has become the most important
wild and domestic canine pathogen since it was first reported in 1978. The virus exhibited …

Viruses hijack cellular proteins, known as viral receptors, to initiate their infections. Viral
receptors are subject to two conflicting directional forces, namely, negative selection to …

Simple Summary Transferrin receptor one (TFR-1), recognized by ferritin, is overexpressed
in many tumor cells. This feature has been exploited to produce a selective overload of …

Abstract The transferrin receptor (TFR-1) has been found to be overexpressed in several
solid tumors in humans and, in clinical oncology, has therefore been exploited in a selective …

H-1 protoparvovirus (H-1PV) is a self-propagating virus, non-pathogenic in humans,
endowed with oncolytic and oncosuppressive activities. H-1PV is the only member of the …

Single-B cell cloning methods enable the production of natural host-derived monoclonal
antibodies against target antigens directly from B cells of key species. They pave the way for …

The recognition of foreign molecules by the canine immune system and mounting a
protective response to viral, bacterial, and parasitic pathogens requires intricate crosstalk …