Early detection of diabetic peripheral neuropathy: a focus on small nerve fibres

J Burgess, B Frank, A Marshall, RS Khalil, G Ponirakis… - Diagnostics, 2021 - mdpi.com
Diabetic peripheral neuropathy (DPN) is the most common complication of both type 1 and 2
diabetes. As a result, neuropathic pain, diabetic foot ulcers and lower-limb amputations …

[HTML][HTML] Corneal confocal microscopy: a biomarker for diabetic peripheral neuropathy

IN Petropoulos, G Ponirakis, M Ferdousi, S Azmi… - Clinical …, 2021 - Elsevier
Purpose Diagnosing early diabetic peripheral neuropathy remains a challenge due to
deficiencies in currently advocated end points. The cornea is densely innervated with small …

Diagnosis of neuropathy and risk factors for corneal nerve loss in type 1 and type 2 diabetes: a corneal confocal microscopy study

M Ferdousi, A Kalteniece, S Azmi… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE To assess the diagnostic utility of corneal confocal microscopy (CCM) for
diabetic peripheral neuropathy (DPN) and the risk factors for corneal nerve loss …

Diagnosing small fiber neuropathy in clinical practice: a deep phenotyping study

N Egenolf, CM Altenschildesche… - Therapeutic …, 2021 - journals.sagepub.com
Background and aims: Small fiber neuropathy (SFN) is increasingly suspected in patients
with pain of uncertain origin, and making the diagnosis remains a challenge lacking a …

Lipids and peripheral neuropathy

Z Iqbal, B Bashir, M Ferdousi, A Kalteniece… - Current Opinion in …, 2021 - journals.lww.com
Hyperlipidaemia, particularly hypertriglyceridemia, is associated with the development and
progression of neuropathy. Lipid modifying agents may represent a potential therapeutic …

Corneal confocal microscopy to image small nerve fiber degeneration: ophthalmology meets neurology

IN Petropoulos, G Bitirgen, M Ferdousi… - Frontiers in Pain …, 2021 - frontiersin.org
Neuropathic pain has multiple etiologies, but a major feature is small fiber dysfunction or
damage. Corneal confocal microscopy (CCM) is a rapid non-invasive ophthalmic imaging …

Corneal confocal microscopy differentiates inflammatory from diabetic neuropathy

M Fleischer, I Lee, F Erdlenbruch, L Hinrichs… - Journal of …, 2021 - Springer
Background Immune-mediated neuropathies, such as chronic inflammatory demyelinating
polyneuropathy (CIDP) are treatable neuropathies. Among individuals with diabetic …

Corneal sub‐basal whorl‐like nerve plexus: a landmark for early and follow‐up evaluation in transthyretin familial amyloid polyneuropathy

Y Zhang, Z Liu, Y Zhang, H Wang, X Liu… - European Journal of …, 2021 - Wiley Online Library
Background and purpose Small‐fiber nerves are the first to be involved in transthyretin
familial amyloid polyneuropathy (TTR‐FAP) patients. In vivo corneal confocal microscopy …

Corneal confocal microscopy identifies Parkinson's disease with more rapid motor progression

SH Lim, M Ferdousi, A Kalteniece… - Movement …, 2021 - Wiley Online Library
Background Corneal confocal microscopy (CCM) is a noninvasive, reproducible ophthalmic
technique to quantify corneal small nerve fiber degeneration. CCM demonstrates small …

Validation of a novel confocal microscopy imaging protocol with assessment of reproducibility and comparison of nerve metrics in dry eye disease compared with …

JS Takhar, AS Joye, SE Lopez, AG Marneris, E Tsui… - Cornea, 2021 - journals.lww.com
Purpose: The purposes of this study were to assess the reproducibility of a novel
standardized technique for capturing corneal subbasal nerve plexus images with in vivo …