The role of BMP15 and GDF9 in the pathogenesis of primary ovarian insufficiency

M Liu, K Zhang, T Xu - Human Fertility, 2021 - Taylor & Francis
Endocrine and paracrine signals can be key regulators of ovarian physiology. The oocyte
secretes growth factors which directly induce follicular development by a complex paracrine …

Onco-fertility and personalized testing for potential for loss of ovarian reserve in patients undergoing chemotherapy: proposed next steps for development of genetic …

B Sun, J Yeh - Fertility Research and Practice, 2021 - Springer
Women of reproductive age undergoing chemotherapy face the risk of irreversible ovarian
insufficiency. Current methods of ovarian reserve testing do not accurately predict future …

Next generation sequencing should be proposed to every woman with “idiopathic” primary ovarian insufficiency

S Eskenazi, A Bachelot, J Hugon-Rodin… - Journal of the …, 2021 - academic.oup.com
Context Primary ovarian insufficiency (POI) affects 1% of women under 40 years of age. POI
is idiopathic in more than 70% of cases. Though many candidate genes have been …

Identification of sequence variation in the oocyte-derived bone morphogenetic protein 15 (BMP15) gene (BMP15) associated with litter size in New Zealand sheep …

HA Najafabadi, M Khansefid, GG Mahmoud… - Molecular Biology …, 2021 - Springer
Advances in the study of reproductive traits indicate that functional variation in fertility genes
may be useful for improving sheep fertility. The aim of this study was to search for variation in …

Targeted next-generation sequencing indicates a frequent oligogenic involvement in primary ovarian insufficiency onset

R Rossetti, S Moleri, F Guizzardi, D Gentilini… - Frontiers in …, 2021 - frontiersin.org
Primary ovarian insufficiency (POI) is one of the major causes of female infertility associated
with the premature loss of ovarian function in about 3.7% of women before the age of 40 …

Characterization of a novel mutation V136L in bone morphogenetic protein 15 identified in a woman affected by POI

E Ferrarini, G De Marco, F Orsolini, E Gianetti… - Journal of Ovarian …, 2021 - Springer
Background Premature ovarian insufficiency (POI) is an ovarian defect characterized by
primary or secondary amenorrhea, hypergonadotropism and hypoestrogenism which occurs …

[HTML][HTML] Two novel mutations in exon 2 of bone morphogenetic protein (BMP) 15 gene in Pakistani infertile females

H Faiza, M Khan, M Rafiq, AA Khan, NA Rind… - Saudi Journal of …, 2021 - Elsevier
Objective To determine the proportion of fertility in Pakistani infertile females and discover if
there are considerable connection among BMP15 gene polymorphism, follicle maturation …

Turner syndrome

P Backeljauw, SD Chernausek, CH Gravholt… - Sperling Pediatric …, 2021 - Elsevier
Turner syndrome (TS) is a disorder of phenotypic females who have one intact X
chromosome and complete or partial absence of their second sex chromosome. This results …

Tissue-Engineered Ovary

MM Laronda - Organ Tissue Engineering, 2021 - Springer
An engineered ovary could benefit a variety of patients with ovarian insufficiency including
those with an inherited condition, de novo mutation, or those whose treatment regimens …

Causes and Genomic Approaches to Female Reproductive Failure. Doctoral Thesis

L Voložonoka - 2021 - dspace.rsu.lv
Clinical recognition of the genetic causes of female reproductive failure using increasingly
advancing genetic technologies to preserve patient safety and move towards personalized …