Large-vessel vasculitis

D Pugh, M Karabayas, N Basu, MC Cid… - Nature Reviews …, 2021 - nature.com
Large-vessel vasculitis (LVV) manifests as inflammation of the aorta and its major branches
and is the most common primary vasculitis in adults. LVV comprises two distinct conditions …

[HTML][HTML] Innate and adaptive immunity in giant cell arteritis

M Akiyama, S Ohtsuki, GJ Berry, DH Liang… - Frontiers in …, 2021 - frontiersin.org
Autoimmune diseases can afflict every organ system, including blood vessels that are
critically important for host survival. The most frequent autoimmune vasculitis is giant cell …

[HTML][HTML] Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study

L Ortiz-Fernández, G Saruhan-Direskeneli… - The American Journal of …, 2021 - cell.com
Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic
study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five …

Aortitis: recent advances, current concepts and future possibilities

D Pugh, P Grayson, N Basu, N Dhaun - Heart, 2021 - heart.bmj.com
Broadly defined, aortitis refers to inflammation of the aorta and incorporates both infectious
and non-infectious aetiologies. As advanced imaging modalities are increasingly …

[HTML][HTML] The Genomic Organization of the LILR Region Remained Largely Conserved Throughout Primate Evolution: Implications for Health And Disease

L Storm, J Bruijnesteijn, NG de Groot… - Frontiers in …, 2021 - frontiersin.org
The genes of the leukocyte immunoglobulin-like receptor (LILR) family map to the leukocyte
receptor complex (LRC) on chromosome 19, and consist of both activating and inhibiting …

[HTML][HTML] KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease

Q Zhang, Y Zheng, M Ning, T Li - BMC Cardiovascular Disorders, 2021 - Springer
Background Myocardial infarction (MI) contributes to high mortality and morbidity and can
also accelerate atherosclerosis, thus inducing recurrent event due to status changing of …

Polymorphisms in TNFAIP3, but not in STAT4, BANK1, BLK, and TNFSF4, are associated with susceptibility to Takayasu arteritis

I Montúfar‑Robles, ME Soto, S Jiménez‑Morales… - Cellular …, 2021 - Elsevier
Background Takayasu arteritis (TAK) is considered a rare disease characterized by
nonspecific inflammation of the large arteries, especially the aorta and its major branches …

Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population

K Hirayasu, J Sun, G Hasegawa, Y Hashikawa… - Journal of Human …, 2021 - nature.com
Leukocyte immunoglobulin (Ig)-like receptors (LILRs) are encoded by members of a human
multigene family, comprising 11 protein-coding genes and two pseudogenes. Among the …

Florence A Aeschlimann, MD MPH1 ORCID ID 0000-0001-7212-9151, Francesca Raimondi, MD2, Tim Leiner, MD PhD3 Giovanni Donato Aquaro, MD4 David …

HB Grotenhuis, FTG Monasterio - jrheum.org
Takayasu arteritis is an idiopathic large-vessel vasculitis that affects young adults and
children and can lead to ischemia and end-organ damage. Vascular imaging is crucial for …