Transcription factors in epithelial ovarian cancer: histotype-specific drivers and novel therapeutic targets
Transcription factors (TFs) are major contributors to cancer risk and somatic development. In
preclinical and clinical studies, direct or indirect inhibition of TF-mediated oncogenic gene …
preclinical and clinical studies, direct or indirect inhibition of TF-mediated oncogenic gene …
[PDF][PDF] H3K27ac HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility
C Giambartolomei, JH Seo, T Schwarz… - The American Journal of …, 2021 - cell.com
Genome-wide association studies (GWASs) have identified more than 200 prostate cancer
(PrCa) risk regions, which provide potential insights into causal mechanisms. Multiple lines …
(PrCa) risk regions, which provide potential insights into causal mechanisms. Multiple lines …
Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing
GWAS have identified numerous SNPs associated with prostate cancer risk. One such SNP
is rs10993994. It is located in the β-microseminoprotein (MSMB) promoter region, mediates …
is rs10993994. It is located in the β-microseminoprotein (MSMB) promoter region, mediates …
[PDF][PDF] Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanisms
A Shetty, JH Seo, CA Bell, EP O'Connor… - The American Journal of …, 2021 - cell.com
Genome-wide association studies (GWASs) of prostate cancer have identified> 250
significant risk loci, but the causal variants and mechanisms for these loci remain largely …
significant risk loci, but the causal variants and mechanisms for these loci remain largely …
Comprehensive analysis of multiple cohort datasets deciphers the utility of germline single-nucleotide polymorphisms in prostate cancer diagnosis
Prostate cancer susceptibility is a polygenic trait. We aimed to examine the controversial
diagnostic utility of single-nucleotide polymorphisms (SNP) for prostate cancer. We analyzed …
diagnostic utility of single-nucleotide polymorphisms (SNP) for prostate cancer. We analyzed …
[HTML][HTML] Family history of prostate cancer and prostate tumor aggressiveness in black and non-black men; results from an equal access biopsy study
KR Jenkins, T Oyekunle, LE Howard, EK Wiggins… - Cancer Causes & …, 2021 - Springer
Purpose To test for racial differences in associations between family history (FH) of prostate
cancer (PC) and prostate cancer aggressiveness in a racially diverse equal access …
cancer (PC) and prostate cancer aggressiveness in a racially diverse equal access …
A hierarchical approach using marginal summary statistics for multiple intermediates in a Mendelian randomization or transcriptome analysis
Previous research has demonstrated the usefulness of hierarchical modeling for
incorporating a flexible array of prior information in genetic association studies. When this …
incorporating a flexible array of prior information in genetic association studies. When this …