Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …

The epithelial-to-mesenchymal transition (EMT), an embryonic program relaunched during
wound healing and in pathological conditions such as fibrosis and cancer, continues to gain …

The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal
development and in cancer progression. EMT is induced by various signaling pathways …

The underpinnings of cancer metastasis remain poorly understood, in part due to a lack of
tools for probing their emergence at high resolution. Here we present macsGESTALT, an …

Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with
certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However …

We present dyngen, a multi-modal simulation engine for studying dynamic cellular
processes at single-cell resolution. dyngen is more flexible than current single-cell …

The PDL1-PD1 immune checkpoint inhibits T cell activation, and its blockade is effective in a
subset of patients. Studies are investigating how checkpoints are hijacked by cancer cells …

Epithelial-mesenchymal transition (EMT) is a developmental process hijacked by cancer
cells to modulate proliferation, migration, and stress response. Whereas kinase signaling is …

The metastatic process is arduous. Cancer cells must escape the confines of the primary
tumor, make their way into and travel through the circulation, then survive and proliferate in …

Identification of novel functional domains and characterization of detailed regulatory
mechanisms in cancer-driving genes is critical for advanced cancer therapy. To date …