Activating killer-cell immunoglobulin-like receptors are associated with the severity of coronavirus disease 2019

E Bernal, L Gimeno, MJ Alcaraz… - The Journal of …, 2021 - academic.oup.com
Background Etiopathogenesis of the clinical variability of the coronavirus disease 2019
(COVID-19) remains mostly unknown. In this study, we investigate the role of killer cell …

KIR3DS1 directs NK cell–mediated protection against human adenovirus infections

JM Jung, W Ching, ME Baumdick… - Science …, 2021 - science.org
Human adenoviruses (HAdVs) are a major cause for disease in children, in particular after
allogeneic hematopoietic stem cell transplantation (allo-HSCT). Currently, effective …

[HTML][HTML] Peptide: MHC-based DNA vaccination strategy to activate natural killer cells by targeting killer cell immunoglobulin-like receptors

P Rettman, MD Blunt, RJ Fulton, AF Vallejo… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Natural killer (NK) cells are increasingly being recognized as agents for cancer
immunotherapy. The killer cell immunoglobulin-like receptors (KIRs) are expressed by NK …

Coexistence of inhibitory and activating killer-cell immunoglobulin-like receptors to the same cognate HLA-C2 and Bw4 ligands confer breast cancer risk

E Ashouri, K Rajalingam, S Barani, S Farjadian… - Scientific reports, 2021 - nature.com
Human leukocyte antigen (HLA) class I-specific killer-cell immunoglobulin-like receptors
(KIR) regulate natural killer (NK) cell function in eliminating malignancy. Breast cancer (BC) …

[图书][B] The impact of target stiffness and tissue localisation on NK cell cytotoxicity

P Simmonds - 2021 - search.proquest.com
Natural Killer (NK) cells play a fundamental role in immunosurveillance by identifying and
killing virally infected or transformed cells. They do this through the lytic immune synapse …

KIR3DS1 Directs NK Cell-mediated Control of Adenovirus and BK Polyomavirus Infection

JM Jung - 2021 - ediss.sub.uni-hamburg.de
Human adenovirus type 5 (HAdV5) and BK polyomavirus (BKPyV) are chronic viruses that
cause severe infections in immunocompromised individuals. Reactivation of HAdV5 is a …