Tissue clearing of gross anatomical samples was first described more than a century ago
and has only recently found widespread use in the field of microscopy. This renaissance has …

Abstract The Human Reference Atlas (HRA) aims to map all of the cells of the human body
to advance biomedical research and clinical practice. This Perspective presents …

Advances in molecular profiling have opened up the possibility to map the expression of
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …

Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …

B-cell maturation antigen (BCMA) is a prominent tumor-associated target for chimeric
antigen receptor (CAR)-T cell therapy in multiple myeloma (MM). Here, we describe the case …

Gene expression fundamentally shapes the structural and functional architecture of the
human brain. Open-access transcriptomic datasets like the Allen Human Brain Atlas provide …

By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades host cells and …

We used the 10x Genomics Visium platform to define the spatial topography of gene
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …

The mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of
the brain metabolome and its changes during diseases or aging remain poorly understood …

The brain is a hugely diverse, heterogeneous structure. Whether or not heterogeneity at the
neural level plays a functional role remains unclear, and has been relatively little explored in …