Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Modulation of chromatin structure and/or modification by Polycomb repressive complexes
(PRCs) provides an important means to partition the genome into functionally distinct …

Mutations are the source of genetic variation and the substrate for evolution. Genome-wide
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …

Abstract The Polycomb group (PcG) protein Enhancer of Zeste Homolog 2 (EZH2) is one of
the three core subunits of the Polycomb Repressive Complex 2 (PRC2). It harbors histone …

Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive
complex 2 (PRC2). Dysregulation of EZH2 causes alteration of gene expression and …

Forkhead box protein A1 (FOXA1) is essential for androgen-dependent prostate cancer
(PCa) growth. However, how FOXA1 levels are regulated remains elusive and its …

Epigenetics is nowadays a well-accepted area of research. In the last years, tremendous
progress was made regarding molecules targeting EZH2, directly or indirectly. Recently …

Protein methylation is a key post-translational modification whose effects on gene
expression have been intensively studied over the last two decades. Recently, renewed …

Abnormal epigenetics is a critical hallmark of human cancers. Anticancer drug discovery
directed at histone epigenetic modulators has gained impressive advances with six drugs …

Enhancer of Zeste Homologue 2 (EZH2) is the catalytic subunit of the polycomb repressive
complex 2 (PRC2) that is critical for determining cell identity. An epigenetic writer, EZH2 has …