[HTML][HTML] Identifying the essential nutritional requirements of the probiotic bacteria Bifidobacterium animalis and Bifidobacterium longum through genome-scale …

M Schöpping, P Gaspar, AR Neves… - NPJ Systems Biology …, 2021 - nature.com
Although bifidobacteria are widely used as probiotics, their metabolism and physiology
remain to be explored in depth. In this work, strain-specific genome-scale metabolic models …

[HTML][HTML] Adaptation of central metabolite pools to variations in growth rate and cultivation conditions in Saccharomyces cerevisiae

K Kumar, V Venkatraman, P Bruheim - Microbial Cell Factories, 2021 - Springer
Background Saccharomyces cerevisiae is a well-known popular model system for basic
biological studies and serves as a host organism for the heterologous production of …

Metabolic and process engineering for microbial production of protocatechuate with Corynebacterium glutamicum

M Labib, J Görtz, C Brüsseler… - Biotechnology and …, 2021 - Wiley Online Library
Dihydroxybenzoate (protocatechuate, PCA) is a phenolic compound naturally found in
edible vegetables and medicinal herbs. PCA is of high interest in the chemical industry and …

[HTML][HTML] Combined Metabolome and Lipidome Analyses for In-Depth Characterization of Lipid Accumulation in the DHA Producing Aurantiochytrium sp. T66

Z Bartosova, H Ertesvåg, EL Nyfløt, K Kämpe, IM Aasen… - Metabolites, 2021 - mdpi.com
Thraustochytrids are marine heterotrophic microorganisms known for their potential to
accumulate docosahexaenoic acid (DHA)-enriched lipids. There have been many attempts …

[HTML][HTML] Robustifying Experimental Tracer Design for13C-Metabolic Flux Analysis

M Beyß, VD Parra-Peña, H Ramirez-Malule… - … in Bioengineering and …, 2021 - frontiersin.org
13C metabolic flux analysis (MFA) has become an indispensable tool to measure metabolic
reaction rates (fluxes) in living organisms, having an increasingly diverse range of …

IMFLer: a web application for interactive metabolic flux analysis and visualization

R Petrovs, E Stalidzans, A Pentjuss - Journal of Computational …, 2021 - liebertpub.com
Increasing genome-wide data in biological sciences and medicine has contributed to the
development of a variety of visualization tools. Several automatic, semiautomatic, and …

Visual exploration of large metabolic models

M Aichem, T Czauderna, Y Zhu, J Zhao… - …, 2021 - academic.oup.com
Motivation Large metabolic models, including genome-scale metabolic models, are
nowadays common in systems biology, biotechnology and pharmacology. They typically …

Visualising metabolic pathways and networks: past, present, future

F Schreiber, E Grafahrend-Belau… - … : History and Future, 2021 - Springer
Visualisations of metabolites and metabolic pathways have been used since the early years
of research in biology, and pathway maps have become very popular in biochemistry …

Metabolic and Process Engineering for Microbial Production of Protocatechuate from Xylose with Corynebacterium glutamicum

M Labib, J Görtz, C Brüsseler, N Kallscheuer… - bioRxiv, 2021 - biorxiv.org
3, 4-Dihydroxybenzoate (protocatechuate, PCA) is a phenolic compound naturally found in
edible vegetables and medicinal herbs. PCA is of interest in the chemical industry as a …

[HTML][HTML] The effect of the expression of the antiapoptotic BHRF1 gene on the metabolic behavior of a hybridoma cell line

I Martínez-Monge, P Comas, D Catalán-Tatjer, J Prat… - Applied Sciences, 2021 - mdpi.com
One of the most important limitations of mammalian cells-based bioprocesses, and
particularly hybridoma cell lines, is the accelerated metabolism related to glucose and …