Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

Corneal diseases are a leading cause of blindness with an estimated 10 million patients
diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly …

The clinical applicability of porcine xenotransplantation—a long-investigated alternative to
the scarce availability of human organs for patients with organ failure—is limited by …

Transplantation of stem cell–derived β (SC-β) cells represents a promising therapy for type 1
diabetes (T1D). However, the delivery, maintenance, and retrieval of these cells remain a …

Transplantable Tissue—Immune and Genome Engineering Dramatic advancements in the
use of synthetic and mechanical devices to replace tissues have been made, but restoring …

Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and
some of them are able to infect human cells. Therefore, PERVs pose a risk for …

Differentiated somatic cells can be reprogrammed to totipotent embryos through somatic cell
nuclear transfer (SCNT) with low efficiency. The histone deacetylase inhibitor trichostatin A …

Accelerated development of novel CRISPR/Cas9-based genome editing techniques
provides a feasible approach to introduce a variety of precise modifications in the …

Lipotoxicity is a recognized pathological trigger and accelerator of nonalcoholic
steatohepatitis (NASH). However, the molecular basis of lipotoxicity-induced NASH remains …

CRISPR gene editing technology belongs to the third generation of gene editing technology.
Since its discovery, it has attracted the attention of a large number of researchers …