[HTML][HTML] Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults: A systematic review and meta-analysis

KE Lafond, RM Porter, MJ Whaley, Z Suizan… - PLoS …, 2021 - journals.plos.org
Background Influenza illness burden is substantial, particularly among young children, older
adults, and those with underlying conditions. Initiatives are underway to develop better …

Management of pneumonia in critically ill patients

C Cillóniz, A Torres, MS Niederman - bmj, 2021 - bmj.com
Severe pneumonia is associated with high mortality (short and long term), as well as
pulmonary and extrapulmonary complications. Appropriate diagnosis and early initiation of …

[HTML][HTML] Recent endemic coronavirus infection is associated with less-severe COVID-19

M Sagar, K Reifler, M Rossi, NS Miller… - The Journal of …, 2021 - Am Soc Clin Investig
Abstract The coronavirus disease 2019 (COVID-19) pandemic continues to cause morbidity
and mortality. Since SARS coronavirus 2 (SARS-CoV-2) was identified as the cause for …

[HTML][HTML] Etiological and epidemiological features of acute respiratory infections in China

ZJ Li, HY Zhang, LL Ren, QB Lu, X Ren… - Nature …, 2021 - nature.com
Nationwide prospective surveillance of all-age patients with acute respiratory infections was
conducted in China between 2009‒2019. Here we report the etiological and …

Bacterial superinfection pneumonia in patients mechanically ventilated for COVID-19 pneumonia

CO Pickens, CA Gao, MJ Cuttica, SB Smith… - American journal of …, 2021 - atsjournals.org
Rationale: Current guidelines recommend patients with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) pneumonia receive empirical antibiotics for suspected …

[HTML][HTML] Trends in respiratory virus circulation following COVID-19-targeted nonpharmaceutical interventions in Germany, January-September 2020: Analysis of …

DY Oh, S Buda, B Biere, J Reiche… - The Lancet Regional …, 2021 - thelancet.com
Background During the initial COVID-19 response, Germany's Federal Government
implemented several nonpharmaceutical interventions (NPIs) that were instrumental in …

[HTML][HTML] The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

AC McQuattie-Pimentel, Z Ren, N Joshi… - The Journal of …, 2021 - Am Soc Clin Investig
Alveolar macrophages orchestrate the response to viral infections. Age-related changes in
these cells may underlie the differential severity of pneumonia in older patients. We …

Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo …

A Dinh, J Ropers, C Duran, B Davido, L Deconinck… - The Lancet, 2021 - thelancet.com
Background Shortening the duration of antibiotic therapy for patients admitted to hospital
with community-acquired pneumonia should help reduce antibiotic consumption and thus …

Updates on community acquired pneumonia management in the ICU

GB Nair, MS Niederman - Pharmacology & therapeutics, 2021 - Elsevier
While the world is grappling with the consequences of a global pandemic related to SARS-
CoV-2 causing severe pneumonia, available evidence points to bacterial infection with …

Short-course antimicrobial therapy for pediatric community-acquired pneumonia: the SAFER randomized clinical trial

JM Pernica, S Harman, AJ Kam, R Carciumaru… - JAMA …, 2021 - jamanetwork.com
Importance Community-acquired pneumonia (CAP) is a common occurrence in childhood;
consequently, evidence-based recommendations for its treatment are required. Objective To …