Current status of clinical trials on tau immunotherapies
C Ji, EM Sigurdsson - Drugs, 2021 - Springer
Tau immunotherapies have advanced from proof-of-concept studies to over a dozen clinical
trials for Alzheimer's disease (AD) and other tauopathies. Mechanistic studies in animal and …
trials for Alzheimer's disease (AD) and other tauopathies. Mechanistic studies in animal and …
[HTML][HTML] “Don't Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer's disease and other tauopathies
Phosphorylation is one of the most prevalent post-translational modifications found in
aggregated tau isolated from Alzheimer's disease (AD) patient brains. In tauopathies like …
aggregated tau isolated from Alzheimer's disease (AD) patient brains. In tauopathies like …
[HTML][HTML] Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
Pancreatic ductal adenocarcinoma (PDAC) is characterized by notorious resistance to
current therapies attributed to inherent tumor heterogeneity and highly desmoplastic and …
current therapies attributed to inherent tumor heterogeneity and highly desmoplastic and …
BBB pathophysiology–independent delivery of siRNA in traumatic brain injury
Small interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of
traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier …
traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier …
Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice
Compelling evidence supports vascular contributions to cognitive impairment and dementia
(VCID) including Alzheimer's disease (AD), but the underlying pathogenic mechanisms and …
(VCID) including Alzheimer's disease (AD), but the underlying pathogenic mechanisms and …
Late-in-life neurodegeneration after chronic sleep loss in young adult mice
JE Owen, Y Zhu, P Fenik, G Zhan, P Bell, C Liu… - Sleep, 2021 - academic.oup.com
Chronic short sleep (CSS) is prevalent in modern societies and has been proposed as a risk
factor for Alzheimer's disease (AD). In support, short-term sleep loss acutely increases levels …
factor for Alzheimer's disease (AD). In support, short-term sleep loss acutely increases levels …
Cobalt induces neurodegenerative damages through Pin1 inactivation in mice and human neuroglioma cells
F Zheng, Y Li, F Zhang, Y Sun, C Zheng, Z Luo… - Journal of Hazardous …, 2021 - Elsevier
Cobalt is a hazardous material that has harmful effects on neurotoxicity. Excessive exposure
to cobalt or inactivation of the unique proline isomerase Pin1 contributes to age-dependent …
to cobalt or inactivation of the unique proline isomerase Pin1 contributes to age-dependent …
[HTML][HTML] Chronic traumatic encephalopathy: update on current clinical diagnosis and management
Chronic traumatic encephalopathy is a disease afflicting individuals exposed to repetitive
neurotrauma. Unfortunately, diagnosis is made by postmortem pathologic analysis, and …
neurotrauma. Unfortunately, diagnosis is made by postmortem pathologic analysis, and …
Inhibition of death-associated protein kinase 1 attenuates cis P-tau and neurodegeneration in traumatic brain injury
Traumatic brain injury (TBI) is the leading cause of mortality and disability in young people
and may lead to the development of progressive neurodegeneration, such as that observed …
and may lead to the development of progressive neurodegeneration, such as that observed …
An update on the association between traumatic brain injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction
L Li, J Liang, H Fu - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Abstract LP Li, JW Liang and HJ Fu. An update on the association between traumatic brain
injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction …
injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction …