Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren's syndrome

MJ Barrera, S Aguilera, I Castro, P Carvajal, D Jara… - Autoimmunity …, 2021 - Elsevier
Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …

The revisited role of interleukin-1 alpha and beta in autoimmune and inflammatory disorders and in comorbidities

P Galozzi, S Bindoli, A Doria, P Sfriso - Autoimmunity reviews, 2021 - Elsevier
The interleukin (IL) 1 family of cytokines is noteworthy to have pleiotropic functions in
inflammation and acquired immunity. Over the last decades, several progresses have been …

Prognostic value of interleukin-18 and its association with other inflammatory markers and disease severity in COVID-19

H Satış, HS Özger, PA Yıldız, K Hızel, Ö Gulbahar… - Cytokine, 2021 - Elsevier
Background The effectual immune response is crucial to defeat viral infections. However,
exuberant immune response with features of macrophage activation syndrome (MAS) lead …

CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death

Y Lévy, A Wiedemann, BP Hejblum, M Durand… - Iscience, 2021 - cell.com
The identification of patients with coronavirus disease 2019 and high risk of severe disease
is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing …

Activation of type I and type II interferon signaling in SARS-CoV-2-positive thyroid tissue of patients dying from COVID-19

AM Poma, A Basolo, D Bonuccelli, A Proietti… - Thyroid, 2021 - liebertpub.com
Background: Thyroid dysfunctions have been reported after Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) infection. However, the biological mechanisms …

Erianin: A direct NLRP3 inhibitor with remarkable anti-inflammatory activity

X Zhang, L Hu, S Xu, C Ye, A Chen - Frontiers in immunology, 2021 - frontiersin.org
Erianin (Eri) is the extract of Dendrobium chrysotoxum Lindl. The NLRP3 inflammasome is a
multiprotein complex that plays key roles in a wide variety of chronic inflammation-driven …

The pathological mechanism and potential application of IL-38 in autoimmune diseases

M Han, X Yuan, X Shi, XY Zhu, Y Su… - Frontiers in …, 2021 - frontiersin.org
Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the
human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the …

Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders

CJM Kane, JC Douglas, T Rafferty… - Journal of …, 2021 - Wiley Online Library
Fetal alcohol spectrum disorders (FASD) are alarmingly common, result in significant
personal and societal loss, and there is no effective treatment for these disorders. Cerebellar …

[HTML][HTML] Introduction on monoclonal antibodies

M Sadeghalvad, N Rezaei - Monoclonal Antibodies, 2021 - intechopen.com
Monoclonal antibodies (mAbs) are a group of antibodies produced by identical clones of B
lymphocytes against a particular antigen. mAbs are identical in several properties such as …

Targeting MyD88 downregulates inflammatory mediators and pathogenic processes in PBMC from DMARDs-naïve rheumatoid arthritis patients

S Ramirez-Perez, E Oregon-Romero… - Frontiers in …, 2021 - frontiersin.org
MyD88-dependent intracellular signalling cascades and subsequently NF-kappaB-mediated
transcription lead to the dynamic inflammatory processes underlying the pathogenesis of …