Microvascular dysfunction in diabetes mellitus and cardiometabolic disease
WB Horton, EJ Barrett - Endocrine reviews, 2021 - academic.oup.com
This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …
Ceramides in metabolism: key lipotoxic players
B Chaurasia, SA Summers - Annual review of physiology, 2021 - annualreviews.org
The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
Uromodulin: roles in health and disease
C Schaeffer, O Devuyst… - Annual review of …, 2021 - annualreviews.org
Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …
protein in physiological conditions. Already described several decades ago, uromodulin has …
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis
Genome-wide association studies (GWAS) for kidney function identified hundreds of risk
regions; however, the causal variants, target genes, cell types, and disease mechanisms …
regions; however, the causal variants, target genes, cell types, and disease mechanisms …
Genetic kidney diseases as an underrecognized cause of chronic kidney disease: the key role of international registry reports
Inherited kidney diseases (IKDs) are among the leading causes of early-onset chronic
kidney disease (CKD) and are responsible for at least 10–15% of cases of kidney …
kidney disease (CKD) and are responsible for at least 10–15% of cases of kidney …
Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies
Abstract Chronic Kidney Disease (CKD) represents a slowly progressive disorder that is
typically silent until late stages, but early intervention can significantly delay its progression …
typically silent until late stages, but early intervention can significantly delay its progression …
Hypertension: Current trends and future perspectives
PG Hunter, FA Chapman… - British Journal of Clinical …, 2021 - Wiley Online Library
Hypertension is a significant and increasing global health issue. It is a leading cause of
cardiovascular disease and premature death worldwide due to its effects on end organs …
cardiovascular disease and premature death worldwide due to its effects on end organs …
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study
Background A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to
developing diabetic kidney disease (DKD), the most common cause globally of end-stage …
developing diabetic kidney disease (DKD), the most common cause globally of end-stage …
The use of 'omics for diagnosing and predicting progression of chronic kidney disease: a scoping review
MA Govender, JT Brandenburg, J Fabian… - Frontiers in …, 2021 - frontiersin.org
Globally, chronic kidney disease (CKD) contributes substantial morbidity and mortality.
Recently, various 'omics platforms have provided insight into the molecular basis of kidney …
Recently, various 'omics platforms have provided insight into the molecular basis of kidney …