Donepezil is a reversible acetylcholinesterase inhibitor that is currently the most commonly
prescribed drug for the treatment of Alzheimer's disease. In general, donepezil is known as a …

Meclofenamate is a nonsteroidal anti-inflammatory drug used in the treatment of mild-to-
moderate pain yet poses a rare risk of hepatotoxicity through an unknown mechanism …

Electrophilically reactive drug metabolites are implicated in many adverse drug reactions. In
this mechanism—termed bioactivation—metabolic enzymes convert drugs into reactive …

Reactive metabolite is commonly considered a risk for drug safety and thus a strategy for
minimizing its formation is the key to drug discovery. Liquid chromatography coupled with …

The process of bioactivation resulting in the formation of electrophilic reactive metabolites
(RMs) is an unattractive feature in investigational drug substances, considering their known …

Pollen allergy is a complex, multicausal disease with rising prevalence across the world.
Currently, pollen allergy is treated mainly by symptom management and allergen-specific …

Over 20% of drug failures and withdrawals in the United States are due to hepatotoxicity
concerns. A major mechanism for hepatotoxicity is the metabolic bioactivation of a parent …

The bile salt export pump BSEP (in humans)/Bsep (in animals) is a member of the ATP-
binding cassette (ABC) superfamily of transport proteins. Its systematic name is ABCB11 …

Plant-based nutraceuticals have paved much attention as they are biocompatible as well as
non-toxic. A similar trend has also been seen in the synthesis of nanomaterials. Phyto …