Human immune diversity: from evolution to modernity
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation
Genome-wide association studies (GWAS) have uncovered thousands of genetic variants
that influence risk for human diseases and traits. Yet understanding the mechanisms by …
that influence risk for human diseases and traits. Yet understanding the mechanisms by …
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
W Van Rheenen, RAA Van Der Spek, MK Bakker… - Nature …, 2021 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …
Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses
Exome association studies to date have generally been underpowered to systematically
evaluate the phenotypic impact of very rare coding variants. We leveraged extensive …
evaluate the phenotypic impact of very rare coding variants. We leveraged extensive …
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair
Macrophage colony-stimulating factor (CSF1) is the primary growth factor required for the
control of monocyte and macrophage differentiation, survival, proliferation and renewal …
control of monocyte and macrophage differentiation, survival, proliferation and renewal …
Genome-wide association study of hospitalized COVID-19 patients in the United Arab Emirates
Background The heterogeneity in symptomatology and phenotypic profile attributable to
COVID-19 is widely unknown. The objective of this manuscript is to conduct a trans-ancestry …
COVID-19 is widely unknown. The objective of this manuscript is to conduct a trans-ancestry …
Lower lymphocyte count is associated with increased risk of Parkinson's disease
Objectives Patients with established Parkinson's disease (PD) display differences in
peripheral blood markers of immune function, including leukocyte differential counts …
peripheral blood markers of immune function, including leukocyte differential counts …
White blood cells and severe COVID-19: a Mendelian randomization study
Increasing evidence shows that white blood cells are associated with the risk of coronavirus
disease 2019 (COVID-19), but the direction and causality of this association are not clear. To …
disease 2019 (COVID-19), but the direction and causality of this association are not clear. To …
[PDF][PDF] Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Despite overlap
between genetic risk loci for ALL and hematologic traits, the etiological relevance of …
between genetic risk loci for ALL and hematologic traits, the etiological relevance of …