Women acquire HIV through sexual transmission. Women worldwide represent half of the
people living with HIV, but young women in endemic areas are disproportionally affected …

Human Immunodeficiency Virus type-1 (HIV-1) establishes a latent viral reservoir soon after
infection, which poses a major challenge for drug treatment and curative strategies. Many …

The majority of HIV infections are established through the genital or rectal mucosa.
Fibroblasts are abundant in these tissues, and although not susceptible to infection, can …

The lack of appropriate experimental models often limits our ability to investigate the
establishment of infections in specific tissues. To reproduce the structural and spatial …

In order to establish productive infection in women, HIV must transverse the vaginal
epithelium and gain access to local target cells. Genital inflammation contributes to the …

Medroxyprogesterone acetate (MPA) is a frequently used hormonal contraceptive that has
been shown to significantly increase HIV-1 susceptibility by approximately 40%. However …

Nascent HIV-1 particles incorporate the viral envelope glycoprotein and multiple host
transmembrane proteins during assembly at the plasma membrane. At least some of these …

We read interesting short communication entitled COVID-19: Brief check through the
pathologist's eye (autopsy archive)[1]. The deaths from severe acute respiratory syndrome …

The chemokine receptor CCR5 is expressed on multiple cell types, including macrophages,
dendritic cells, and T cells, and is the major co-receptor used during HIV transmission. Using …

The human female reproductive tract (FRT) is a unique mucosal surface with two competing
functions: creating an immunological environment conducive to successful reproduction …