Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

Understanding the genetic and epigenetic bases of cellular senescence is instrumental in
developing interventions to slow aging. We performed genome-wide CRISPR-Cas9–based …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

The coactivator p300/CREB-binding protein (CBP) regulates genes by facilitating the
assembly of transcriptional machinery and by acetylating histones and other factors …

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to
induce cancer cell cycle arrest. Recent studies have suggested that these agents also exert …

Background Cellular senescence is a permanent state of replicative arrest defined by a
specific pattern of gene expression. The epigenome in senescent cells is sculptured in order …

Chromatin organization and transcriptional profiles undergo tremendous reordering during
senescence. However, uncovering the regulatory mechanisms between chromatin …

The aging proteostasis decline manifests in a failure of aging cells and organisms to
properly respond to proteotoxic challenges. This proteostasis collapse has long been …