The looming storm: blood and cytokines in COVID-19

S Kaur, R Bansal, S Kollimuttathuillam, AM Gowda… - Blood reviews, 2021 - Elsevier
A novel coronavirus termed as COVID-19 by WHO has been the causative agent of an
unprecedented pandemic in the history of humanity. The global burden of mortality and …

Tumor metastasis: Mechanistic insights and therapeutic interventions

M Liu, J Yang, B Xu, X Zhang - MedComm, 2021 - Wiley Online Library
Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

COVID-19: famotidine, histamine, mast cells, and mechanisms

RW Malone, P Tisdall, P Fremont-Smith, Y Liu… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19
differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not …

Multifaceted roles of chemokines and chemokine receptors in tumor immunity

K Matsuo, O Yoshie, T Nakayama - Cancers, 2021 - mdpi.com
Simple Summary Various immune cells are involved in host immune responses to cancer. T-
helper (Th) 1 cells, cytotoxic CD8+ T cells, and natural killer cells are the major effector cells …

Targeted treatment of alcoholic liver disease based on inflammatory signalling pathways

B Wen, C Zhang, J Zhou, Z Zhang, Q Che… - Pharmacology & …, 2021 - Elsevier
Targeted therapy is an emerging treatment strategy for alcoholic liver disease (ALD).
Inflammation plays an important role in the occurrence and development of ALD, and is a …

Biased agonism at chemokine receptors

DS Eiger, N Boldizsar, CC Honeycutt, J Gardner… - Cellular signalling, 2021 - Elsevier
In the human chemokine system, interactions between the approximately 50 known
endogenous chemokine ligands and 20 known chemokine receptors (CKRs) regulate a …

Nano-based approaches in the development of antiviral agents and vaccines

Y Li, Y Xiao, Y Chen, K Huang - Life sciences, 2021 - Elsevier
Outbreaks and the rapid transmission of viruses, such as coronaviruses and influenza
viruses, are serious threats to human health. A major challenge in combating infectious …

Drug discovery of nucleos (t) ide antiviral agents: dedicated to Prof. Dr. Erik De Clercq on occasion of his 80th birthday

G Li, T Yue, P Zhang, W Gu, LJ Gao, L Tan - Molecules, 2021 - mdpi.com
Nucleoside and nucleotide analogues are essential antivirals in the treatment of infectious
diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C …

Genetic diversity of SARS-CoV-2 over a one-year period of the COVID-19 pandemic: a global perspective

M Miao, ED Clercq, G Li - Biomedicines, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic
of coronavirus disease in 2019 (COVID-19). Genome surveillance is a key method to track …

Addressing antiretroviral drug resistance with host-targeting drugs—First steps towards developing a host-targeting hiv-1 assembly inhibitor

JR Lingappa, VR Lingappa, JC Reed - Viruses, 2021 - mdpi.com
The concerning increase in HIV-1 resistance argues for prioritizing the development of host-
targeting antiviral drugs because such drugs can offer high genetic barriers to the selection …