SARS‐CoV‐2‐neutralising monoclonal antibodies for treatment of COVID‐19

KL Chai, E Tomlinson, Z Khosravi… - Cochrane Database …, 2021 - cochranelibrary.com
Background Monoclonal antibodies (mAbs) are laboratory‐produced molecules derived
from the B cells of an infected host. They are being investigated as a potential therapy for …

SARS-CoV-2 antiviral therapy

K Tao, PL Tzou, J Nouhin, H Bonilla… - Clinical microbiology …, 2021 - Am Soc Microbiol
The development of effective antiviral therapy for COVID-19 is critical for those awaiting
vaccination, as well as for those who do not respond robustly to vaccination. This review …

[HTML][HTML] Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline

JD Chalmers, ML Crichton… - European respiratory …, 2021 - Eur Respiratory Soc
Introduction Hospitalised patients with coronavirus disease 2019 (COVID-19) as a result of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have a high …

[HTML][HTML] A neutralizing monoclonal antibody for hospitalized patients with Covid-19

Activ-3/Tico Ly-CoV555 Study … - New England Journal of …, 2021 - Mass Medical Soc
Background LY-CoV555, a neutralizing monoclonal antibody, has been associated with a
decrease in viral load and the frequency of hospitalizations or emergency department visits …

Antibody and cellular therapies for treatment of covid-19: a living systematic review and network meta-analysis

RAC Siemieniuk, JJ Bartoszko, JPD Martinez, E Kum… - Bmj, 2021 - bmj.com
Objective To evaluate the efficacy and safety of antiviral antibody therapies and blood
products for the treatment of novel coronavirus disease 2019 (covid-19). Design Living …

Platelets amplify endotheliopathy in COVID-19

TJ Barrett, MI Cornwell, K Myndzar, CC Rolling… - Science …, 2021 - science.org
Given the evidence for a hyperactive platelet phenotype in COVID-19, we investigated
effector cell properties of COVID-19 platelets on endothelial cells (ECs). Integration of EC …

[HTML][HTML] A systematic review and meta-analysis of inpatient mortality associated with nosocomial and community COVID-19 exposes the vulnerability of …

MJ Ponsford, TJC Ward, SM Stoneham… - Frontiers in …, 2021 - frontiersin.org
Background Little is known about the mortality of hospital-acquired (nosocomial) COVID-19
infection globally. We investigated the risk of mortality and critical care admission in …

[HTML][HTML] COVID-19 in B cell-depleted patients after rituximab: a diagnostic and therapeutic challenge

A Furlan, G Forner, L Cipriani, E Vian, R Rigoli… - Frontiers in …, 2021 - frontiersin.org
B cell-targeting strategies such as rituximab are widely used in B cell hematologic
malignancies, rheumatologic and musculoskeletal diseases and a variety of autoimmune …

[PDF][PDF] Interferon gamma immunotherapy in five critically ill COVID-19 patients with impaired cellular immunity: A case series

A van Laarhoven, L Kurver, GJ Overheul, EJ Kooistra… - Med, 2021 - cell.com
Background Prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
shedding has been described in immunocompromised coronavirus disease 2019 (COVID …

Effect of colchicine vs usual care alone on intubation and 28-day mortality in patients hospitalized with COVID-19: a randomized clinical trial

R Diaz, A Orlandini, N Castellana, A Caccavo… - JAMA Network …, 2021 - jamanetwork.com
Importance Hospitalized patients with COVID-19 pneumonia have high rates of morbidity
and mortality. Objective To assess the efficacy of colchicine in hospitalized patients with …