[HTML][HTML] Dry powder for pulmonary delivery: A comprehensive review

B Chaurasiya, YY Zhao - Pharmaceutics, 2021 - mdpi.com
The pulmonary route has long been used for drug administration for both local and systemic
treatment. It possesses several advantages, which can be categorized into physiological, ie …

Dry powder pharmaceutical biologics for inhalation therapy

RYK Chang, MYT Chow, D Khanal, D Chen… - Advanced Drug Delivery …, 2021 - Elsevier
Therapeutic biologics such as genes, peptides, proteins, virus and cells provide clinical
benefits and are becoming increasingly important tools in respiratory medicine. Pulmonary …

Aerosolizable siRNA-encapsulated solid lipid nanoparticles prepared by thin-film freeze-drying for potential pulmonary delivery

JL Wang, MS Hanafy, H Xu, J Leal, Y Zhai… - International Journal of …, 2021 - Elsevier
Lipid nanoparticles are increasingly used for drug and gene delivery, including the delivery
of small interfering RNA (siRNA). Pulmonary delivery of drug molecules carried by lipid …

Particle engineering principles and technologies for pharmaceutical biologics

D Cun, C Zhang, H Bera, M Yang - Advanced Drug Delivery Reviews, 2021 - Elsevier
The global market of pharmaceutical biologics has expanded significantly during the last few
decades. Currently, pharmaceutical biologic products constitute an indispensable part of the …

A comparative study of encapsulation of carotenoid enriched-flaxseed oil and flaxseed oil by spray freeze-drying and spray drying techniques

A Elik, DK Yanık, F Göğüş - Lwt, 2021 - Elsevier
Encapsulation of carotenoid enriched flaxseed oil was performed by spray freeze-drying by
using sixteen different emulsion formulations. Emulsions, which contain various …

[HTML][HTML] Nanoparticles as an effective drug delivery system in COVID-19

NK Chowdhury, R Choudhury, GA Sonawane… - Biomedicine & …, 2021 - Elsevier
Background The global healthcare sector has been dealing with a situation known as a
novel severe acute respiratory syndrome (SARS-CoV-2) since the end of 2019. Covid-19 is …

Efficient Inhibition of SARS‐CoV‐2 Using Chimeric Antisense Oligonucleotides through RNase L Activation

X Su, W Ma, D Feng, B Cheng, Q Wang… - Angewandte …, 2021 - Wiley Online Library
There is an urgent need to develop antiviral drugs and alleviate the current COVID‐19
pandemic. Herein we report the design and construction of chimeric oligonucleotides …

[HTML][HTML] A pathway from porous particle technology toward tailoring aerogels for pulmonary drug administration

T Duong, C López-Iglesias, PK Szewczyk… - … in Bioengineering and …, 2021 - frontiersin.org
Pulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry
powder inhalers (DPIs) are convenient, portable and environmentally friendly devices …

[HTML][HTML] Inhalable protein powder prepared by spray-freeze-drying using hydroxypropyl-β-cyclodextrin as excipient

JCK Lo, HW Pan, JKW Lam - Pharmaceutics, 2021 - mdpi.com
The prospect of inhaled biologics has garnered particular interest given the benefits of the
pulmonary route of administration. Pertinent considerations in producing inhalable dry …

siRNA delivery to macrophages using aspherical, nanostructured microparticles as delivery system for pulmonary administration

T Fischer, T Tschernig, F Drews, K Brix, C Meier… - European Journal of …, 2021 - Elsevier
The delivery of oligonucleotides such as siRNA to the lung is a major challenge, as this
group of drugs has difficulties to overcome biological barriers due to its polyanionic …