Emerging role of carbonic anhydrase inhibitors
CT Supuran - Clinical Science, 2021 - portlandpress.com
Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …
most modern diuretics were obtained considering as lead molecule acetazolamide, the …
The therapeutic importance of acid-base balance
BN Quade, MD Parker, R Occhipinti - Biochemical pharmacology, 2021 - Elsevier
Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …
Understanding the antioxidant and carbonyl sequestering activity of carnosine: Direct and indirect mechanisms
Carnosine is an endogenous dipeptide whose oral administration has been found to prevent
several oxidative based diseases including lung disease, type 2 diabetes and its micro and …
several oxidative based diseases including lung disease, type 2 diabetes and its micro and …
Endothelial response to glucose: dysfunction, metabolism, and transport
AM Clyne - Biochemical Society Transactions, 2021 - portlandpress.com
The endothelial cell response to glucose plays an important role in both health and disease.
Endothelial glucose-induced dysfunction was first studied in diabetic animal models and in …
Endothelial glucose-induced dysfunction was first studied in diabetic animal models and in …
Dissecting the crosstalk between endothelial mitochondrial damage, vascular inflammation, and neurodegeneration in cerebral amyloid angiopathy and Alzheimer's …
Alzheimer's disease (AD) is the most prevalent cause of dementia and is pathologically
characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) …
characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) …
Carbonic anhydrases as potential targets against neurovascular unit dysfunction in Alzheimer's disease and stroke
The Neurovascular Unit (NVU) is an important multicellular structure of the central nervous
system (CNS), which participates in the regulation of cerebral blood flow (CBF), delivery of …
system (CNS), which participates in the regulation of cerebral blood flow (CBF), delivery of …
Novel carbonic anhydrase inhibitors
CT Supuran - Future Medicinal Chemistry, 2021 - Taylor & Francis
Carbonic anhydrases (CAs; EC 4.2. 1.1) are ubiquitous enzymes which catalyze the
interconversion between CO2 and bicarbonate, which is involved in the regulation of pH and …
interconversion between CO2 and bicarbonate, which is involved in the regulation of pH and …
Impact of tau on neurovascular pathology in Alzheimer's disease
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most prevalent
cause of dementia. The main cerebral histological hallmarks are represented by …
cause of dementia. The main cerebral histological hallmarks are represented by …
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases
A Petreni, SM Osman, FA Alasmary… - European Journal of …, 2021 - Elsevier
The first structural analysis comparing the binding mode to the target carbonic anhydrases
(CAs, EC 4.2. 1.1) of two opposite classes of modulators is presented here: coumarin …
(CAs, EC 4.2. 1.1) of two opposite classes of modulators is presented here: coumarin …
Development of novel quinoline-based sulfonamides as selective cancer-associated carbonic anhydrase isoform IX inhibitors
A new series of quinoline-based benzenesulfonamides (QBS) were developed as potential
carbonic anhydrase inhibitors (CAIs). The target QBS CAIs is based on the 4 …
carbonic anhydrase inhibitors (CAIs). The target QBS CAIs is based on the 4 …