Chromatin remodelers act to regulate multiple cellular processes, such as transcription and
DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers …

The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor
suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at …

Abstract Neurofibromatosis type 1 (NF1), type 2 (NF2), and schwannomatosis are a group of
autosomal dominant disorders that predispose to the development of nerve sheath tumors …

PBRM1, a subunit of the PBAF coactivator complex that transcription factors use to activate
target genes, is genetically inactivated in almost all clear cell renal cell cancers (RCCs) …

Purpose Chromatin remodeling plays an essential role in regulating transcriptional networks
and timing of gene expression. Chromatin remodelers such as SWItch/Sucrose Non …

Dear Editor, SWI/SNF is the prototype chromatin remodeling complex and regulates the
expression of 5% genes in yeast 1. It shows strong homology to RSC in yeast and the BAF …

Objectives SWI/SNF‐related matrix‐associated actin‐dependent regulator of chromatin
subfamily B member 1 (SMARCB1) loss is associated with a poor prognosis in chordoma …

During development, gene expression is tightly controlled to facilitate the generation of the
diverse cell types that form the central nervous system. Brahma-related gene 1 (Brg1, also …

Molecular function within the cell is not only the information present in the DNA but also how
it is being processed. Histones play an important role in regulating these processes …

Endothelial cells (ECs) are constantly subjected to an array of mechanical cues, especially
shear stress, due to their luminal placement in the blood vessels. Blood flow can regulate …