[HTML][HTML] The Drosophila ortholog of the schizophrenia-associated CACNA1A and CACNA1B voltage-gated calcium channels regulate memory, sleep and circadian …

S Hidalgo, JM Campusano, JJL Hodge - Neurobiology of Disease, 2021 - Elsevier
Schizophrenia exhibits up to 80% heritability. A number of genome wide association studies
(GWAS) have repeatedly shown common variants in voltage-gated calcium (Ca v) channel …

Assessing olfactory, memory, social and circadian phenotypes associated with schizophrenia in a genetic model based on Rim

S Hidalgo, JM Campusano, JJL Hodge - Translational Psychiatry, 2021 - nature.com
Schizophrenia shows high heritability and several of the genes associated with this disorder
are involved in calcium (Ca2+) signalling and synaptic function. One of these is the Rab-3 …

Schizophrenia‐associated gene dysbindin‐1 and tardive dyskinesia

MS Maes, JY Lu, AK Tiwari, N Freeman… - Drug Development …, 2021 - Wiley Online Library
Tardive dyskinesia (TD) is a potentially irreversible movement disorder observed following
long‐term antipsychotic exposure. Its cause is unknown; however, a genetic component has …

Astrocytic Regulation of Basal Ganglia Dopamine/D2-Dependent Behaviors

R Mastrogiacomo, G Trigilio, D Dautan, C Devroye… - bioRxiv, 2021 - biorxiv.org
Astrocytic involvement in dopamine dynamics related to motivational and sensorimotor
gating abilities is unknown. We found that dysbindin-1 (Dys1) hypofunction increases the …