Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Cell membrane‐bound serine proteases are important in the maintenance of physiological
homeostasis. Hepsin is a type II transmembrane serine protease highly expressed in the …

Hypertension is a significant risk factor for cardiovascular disease and mortality worldwide.
The kidney is a major regulator of blood pressure and electrolyte homeostasis, with …

Neural network‐based models for protein structure prediction have recently reached near‐
experimental accuracy and are fast becoming a powerful tool in the arsenal of biologists. As …

Abstract Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) exist in a variety of
oligomeric forms, each with defined cellular and subcellular distributions. Although crystal …

Modification of host receptor proteins with sugars, or glycosylation, is essential for the
binding of many pathogens. For instance, group B streptococcus, Helicobacter pylori, and …

Type 1 pili have long been considered the major virulence factor enabling colonization of
the urinary bladder by uropathogenic Escherichia coli (UPEC). The molecular pathogenesis …