The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …

Prostate cancer is the most commonly diagnosed non-cutaneous cancers in North American
men. While androgen deprivation has remained as the cornerstone of prostate cancer …

Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment,
innovation and development of new effective anticancer candidates still represents a …

Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on
lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene …

Summary p53-binding protein 1 (53BP1) regulates both the DNA damage response and p53
signaling. Although 53BP1's function is well established in DNA double-strand break repair …

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful
model system to uncover fundamental mechanisms that control cellular identity during …

Genomic amplification of OTUD7B is frequently found across human cancers. But its role in
tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

Simple Summary Disruption of the balance between cell division and cell death (apoptosis)
is an extremely important factor contributing to cancer formation and progression. While …