Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Nuclear chromosomes transcribe far more RNA than required to encode protein. Here we
investigate whether non-coding RNA broadly contributes to cytological-scale chromosome …

Cellular senescence is a stable form of cell cycle arrest in response to various stressors.
While it serves as an endogenous pro-resolving mechanism, detrimental effects ensue when …

Decline in ovarian reserve with advancing age is associated with reduced fertility and the
emergence of metabolic disturbances, osteoporosis, and neurodegeneration. Recent …

Cellular senescence is an irreversible cell cycle arrest implemented by the cell as a result of
stressful insults. Characterized by phenotypic alterations, including secretome changes and …

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity for all sexes,
racial and ethnic groups. Age, and its associated physiological and pathological …

The aging proteostasis decline manifests in a failure of aging cells and organisms to
properly respond to proteotoxic challenges. This proteostasis collapse has long been …

Rank signaling enhances stemness in mouse and human mammary epithelial cells (MECs)
and mediates mammary tumor initiation. Mammary tumors initiated by oncogenes or …