[HTML][HTML] Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
Remdesivir is the only FDA-approved drug for the treatment of COVID-19 patients. The
active form of remdesivir acts as a nucleoside analog and inhibits the RNA-dependent RNA …
active form of remdesivir acts as a nucleoside analog and inhibits the RNA-dependent RNA …
Structural basis for backtracking by the SARS-CoV-2 replication–transcription complex
Backtracking, the reverse motion of the transcriptase enzyme on the nucleic acid template, is
a universal regulatory feature of transcription in cellular organisms but its role in viruses is …
a universal regulatory feature of transcription in cellular organisms but its role in viruses is …
Nanopores: a versatile tool to study protein dynamics
Proteins are the active workhorses in our body. These biomolecules perform all vital cellular
functions from DNA replication and general biosynthesis to metabolic signaling and …
functions from DNA replication and general biosynthesis to metabolic signaling and …
Mechanisms of inhibition of viral RNA replication by nucleotide analogs
KA Johnson, T Dangerfield - The Enzymes, 2021 - Elsevier
Nucleotide analogs are the cornerstone of direct acting antivirals used to control infection by
RNA viruses. Here we review what is known about existing nucleotide/nucleoside analogs …
RNA viruses. Here we review what is known about existing nucleotide/nucleoside analogs …
Structural insight into the substrate scope of viperin and viperin-like enzymes from three domains of life
JC Lachowicz, AS Gizzi, SC Almo, TL Grove - Biochemistry, 2021 - ACS Publications
Viperin is a member of the radical S-adenosylmethionine superfamily and has been shown
to restrict the replication of a wide range of RNA and DNA viruses. We recently …
to restrict the replication of a wide range of RNA and DNA viruses. We recently …
[HTML][HTML] The nucleotide addition cycle of the SARS-CoV-2 polymerase
SC Bera, M Seifert, RN Kirchdoerfer, P van Nies… - Cell reports, 2021 - cell.com
Coronaviruses have evolved elaborate multisubunit machines to replicate and transcribe
their genomes. Central to these machines are the RNA-dependent RNA polymerase subunit …
their genomes. Central to these machines are the RNA-dependent RNA polymerase subunit …
Chemical synthesis of the antiviral nucleotide analogue ddhCTP
3′-Deoxy-3′, 4′-didehydro-cytidine triphosphate (ddhCTP) is a novel antiviral molecule
produced by the enzyme viperin as part of the innate immune response. ddhCTP has been …
produced by the enzyme viperin as part of the innate immune response. ddhCTP has been …
A chemical strategy for intracellular arming of an endogenous broad-Spectrum antiviral nucleotide
KT Passow, HS Caldwell, KA Ngo… - Journal of medicinal …, 2021 - ACS Publications
The naturally occurring nucleotide 3′-deoxy-3′, 4′-didehydro-cytidine-5′-triphosphate
(ddhCTP) was recently found to exert potent and broad-spectrum antiviral activity. However …
(ddhCTP) was recently found to exert potent and broad-spectrum antiviral activity. However …
Ensemble cryo-electron microscopy reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex
The SARS-CoV-2 nonstructural proteins coordinate genome replication and gene
expression. Structural analyses revealed the basis for coupling of the essential nsp13 …
expression. Structural analyses revealed the basis for coupling of the essential nsp13 …