Bacterial terpenome

JD Rudolf, TA Alsup, B Xu, Z Li - Natural product reports, 2021 - pubs.rsc.org
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Natural products against key Mycobacterium tuberculosis enzymatic targets: Emerging opportunities for drug discovery

G Cazzaniga, M Mori, LR Chiarelli, A Gelain… - European journal of …, 2021 - Elsevier
For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …

Recent developments on the synthesis and bioactivity of ilamycins/rufomycins and cyclomarins, marine cyclopeptides that demonstrate anti-malaria and anti …

U Kazmaier, L Junk - Marine Drugs, 2021 - mdpi.com
Ilamycins/rufomycins and cyclomarins are marine cycloheptapeptides containing unusual
amino acids. Produced by Streptomyces sp., these compounds show potent activity against …

ClpXP-mediated degradation of the TAC antitoxin is neutralized by the SecB-like chaperone in Mycobacterium tuberculosis

P Texier, P Bordes, J Nagpal, AJ Sala… - Journal of molecular …, 2021 - Elsevier
Bacterial toxin-antitoxin (TA) systems are composed of a deleterious toxin and its
antagonistic antitoxin. They are widespread in bacterial genomes and mobile genetic …

Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria

P Labana, MH Dornan, M Lafrenière, TL Czarny… - Cell Chemical …, 2021 - cell.com
Multi-drug-resistant bacteria present an urgent threat to modern medicine, creating a
desperate need for antibiotics with new modes of action. As natural products remain an …

Exploring a potential Achilles heel of Mycobacterium tuberculosis: defining the ClpC1 interactome

DA Dougan, R Alver, K Turgay - The FEBS Journal, 2021 - Wiley Online Library
Protein degradation plays a vital role in the correct maintenance of a cell, not only under
normal physiological conditions but also in response to stress. In bacteria, this crucial …

Identification of diverse targets of arginine phosphorylation in Mycolicibacterium smegmatis by shotgun proteomics

EC Ogbonna, KR Schmitz - bioRxiv, 2021 - biorxiv.org
Tuberculosis is a leading cause of worldwide infectious mortality. The prevalence of
multidrug-resistant Mycobacterium tuberculosis (Mtb) infections drives an urgent need to …

Inhibitory effects of salinispora-derived metabolites against multidrug resistance: an in-silico study

M Ghandadi - Pharmaceutical and Biomedical …, 2021 - publish.kne-publishing.com
Background: Multi Drug Resistance (MDR) is known to defeat most chemotherapies as one
of the main anticancer strategies. The role of overexpression or overactivation of …

[PDF][PDF] Facultad de Ciencias y Filosofia

SAR Désir - 2021 - repositorio.upch.edu.pe
Artística, es el órgano del Ministerio de Educación responsable, entre otras funciones ya
través de sus órganos de línea, de diseñar y formular las políticas, planes y documentos …

[PDF][PDF] Ensemble-based virtual screening of Mycobacterium tuberculosis ClpC1 inhibitors

H Tayyab, NFW Ridzwan, SB Mohamad - Beilstein Archives, 2021 - beilstein-journals.org
Tuberculosis (TB) is an airborne transmissible disease caused by Mycobacterium
tuberculosis (Mtb), responsible for 1.3 million deaths per year. Due to increased cases of …