G Cazzaniga, M Mori, LR Chiarelli, A Gelain… - European journal of …, 2021 - Elsevier
For centuries, natural products (NPs) have served as powerful therapeutics against a variety of human ailments. Nowadays, they still represent invaluable resources for the treatment of …
U Kazmaier, L Junk - Marine Drugs, 2021 - mdpi.com
Ilamycins/rufomycins and cyclomarins are marine cycloheptapeptides containing unusual amino acids. Produced by Streptomyces sp., these compounds show potent activity against …
P Texier, P Bordes, J Nagpal, AJ Sala… - Journal of molecular …, 2021 - Elsevier
Bacterial toxin-antitoxin (TA) systems are composed of a deleterious toxin and its antagonistic antitoxin. They are widespread in bacterial genomes and mobile genetic …
P Labana, MH Dornan, M Lafrenière, TL Czarny… - Cell Chemical …, 2021 - cell.com
Multi-drug-resistant bacteria present an urgent threat to modern medicine, creating a desperate need for antibiotics with new modes of action. As natural products remain an …
DA Dougan, R Alver, K Turgay - The FEBS Journal, 2021 - Wiley Online Library
Protein degradation plays a vital role in the correct maintenance of a cell, not only under normal physiological conditions but also in response to stress. In bacteria, this crucial …
Tuberculosis is a leading cause of worldwide infectious mortality. The prevalence of multidrug-resistant Mycobacterium tuberculosis (Mtb) infections drives an urgent need to …
M Ghandadi - Pharmaceutical and Biomedical …, 2021 - publish.kne-publishing.com
Background: Multi Drug Resistance (MDR) is known to defeat most chemotherapies as one of the main anticancer strategies. The role of overexpression or overactivation of …
Artística, es el órgano del Ministerio de Educación responsable, entre otras funciones ya través de sus órganos de línea, de diseñar y formular las políticas, planes y documentos …
Tuberculosis (TB) is an airborne transmissible disease caused by Mycobacterium tuberculosis (Mtb), responsible for 1.3 million deaths per year. Due to increased cases of …