The new kid on the block: HLA-C, a key regulator of natural killer cells in viral immunity
S Vollmers, A Lobermeyer, C Körner - Cells, 2021 - mdpi.com
The human leukocyte antigen system (HLA) is a cluster of highly polymorphic genes
essential for the proper function of the immune system, and it has been associated with a …
essential for the proper function of the immune system, and it has been associated with a …
Relevance of polymorphic KIR and HLA class I genes in NK-cell-based immunotherapies for adult leukemic patients
L Dubreuil, P Chevallier, C Retière, K Gagne - Cancers, 2021 - mdpi.com
Simple Summary Immunotherapies are promising approaches to curing different acute
leukemias. Natural killer (NK) cells are lymphocytes that are efficient in the elimination of …
leukemias. Natural killer (NK) cells are lymphocytes that are efficient in the elimination of …
ERAP1 controls the autoimmune response against melanocytes in psoriasis by generating the melanocyte autoantigen and regulating its amount for HLA-C* 06: 02 …
A Arakawa, E Reeves, S Vollmer… - The Journal of …, 2021 - journals.aai.org
Autoimmune diseases develop when autoantigens activate previously quiescent self-
reactive lymphocytes. Gene–gene interaction between certain HLA class I risk alleles and …
reactive lymphocytes. Gene–gene interaction between certain HLA class I risk alleles and …
[PDF][PDF] Precision neoantigen discovery using large-scale immunopeptidomes and composite modeling of MHC peptide presentation
Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite
Modeling of MHC Peptide Presentation Page 1 Precision Neoantigen Discovery Using …
Modeling of MHC Peptide Presentation Page 1 Precision Neoantigen Discovery Using …
Anthem: a user customised tool for fast and accurate prediction of binding between peptides and HLA class I molecules
Neopeptide-based immunotherapy has been recognised as a promising approach for the
treatment of cancers. For neopeptides to be recognised by CD8+ T cells and induce an …
treatment of cancers. For neopeptides to be recognised by CD8+ T cells and induce an …
[HTML][HTML] An immunogenetic view of COVID-19
Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary
approach. In this context, integrating knowledge of immune function with an understanding …
approach. In this context, integrating knowledge of immune function with an understanding …
Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity
Human leukocyte antigen class I (HLA-I) genes shape our immune response against
pathogens and cancer. Certain HLA-I variants can bind a wider range of peptides than …
pathogens and cancer. Certain HLA-I variants can bind a wider range of peptides than …
HLA RNA sequencing with unique molecular identifiers reveals high allele-specific variability in mRNA expression
T Johansson, DA Yohannes, S Koskela… - Frontiers in …, 2021 - frontiersin.org
The HLA gene complex is the most important single genetic factor in susceptibility to most
diseases with autoimmune or autoinflammatory origin and in transplantation matching. Most …
diseases with autoimmune or autoinflammatory origin and in transplantation matching. Most …
Delineating Novel Therapeutic Drug and Vaccine Targets for Staphylococcus cornubiensis NW1T Through Computational Analysis
Staphylococcal multidrug resistance is an emerging future threat. Among staphylococci
species, Staphylococcus intermedius group (SIG) comprises of coagulase-positive four …
species, Staphylococcus intermedius group (SIG) comprises of coagulase-positive four …
21-Hydroxylase-specific CD8+ T cells in autoimmune Addison's disease are restricted by HLA-A2 and HLA-C7 molecules
A Hellesen, S Aslaksen, L Breivik, EC Røyrvik… - Frontiers in …, 2021 - frontiersin.org
Objectives CD8+ T cells targeting 21-hydroxylase (21OH) are presumed to play a central
role in the destruction of adrenocortical cells in autoimmune Addison's disease (AAD) …
role in the destruction of adrenocortical cells in autoimmune Addison's disease (AAD) …