The airway epithelium protects us from environmental insults, which we encounter with
every breath. Not only does it passively filter large particles, it also senses potential danger …

Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

Proper lung function relies on the precise balance of specialized epithelial cells that
coordinate to maintain homeostasis. Herein, we describe essential roles for the …

TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the
United States and is primarily caused by cigarette smoking. Increased numbers of mucus …

Activation of the Ca2+ activated Cl− channel TMEM16A is proposed as a treatment in
inflammatory airway disease. It is assumed that activation of TMEM16A will induce …

Multiciliated cells (MCCs) are extremely highly differentiated, presenting> 100 cilia and
basal bodies. Therefore, MCC fate is thought to be terminal and irreversible. We analyzed …

Recent studies have focused their attention on conjunctivitis as one of the symptoms of
coronavirus disease 2019 (COVID-19). Therefore, tear samples were taken from COVID-19 …

Dupilumab is a dual inhibitor of interleukin-4 and interleukin-13 and is mainly used to treat
moderate-to-severe atopic dermatitis. Post-marketing safety data related to dupilumab have …

Epithelial cells of the conducting airways are a pivotal first line of defense against airborne
pathogens and allergens that orchestrate inflammatory responses and mucociliary …