T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …

Use of adaptive immune receptor repertoire sequencing (AIRR-seq) has become
widespread, providing new insights into the immune system with potential broad clinical and …

Monitoring the T cell receptor (TCR) repertoire in health and disease can provide key
insights into adaptive immune responses, but the accuracy of current TCR sequencing …

Adaptive immune receptor repertoires (AIRR) are key targets for biomedical research as
they record past and ongoing adaptive immune responses. The capacity of machine …

It is increasingly clear that an extraordinarily diverse range of clinically important conditions—
including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions …

Celiac disease (CeD) is a common autoimmune disorder caused by an abnormal immune
response to dietary gluten proteins. The disease has high heritability. HLA is the major …

Over the last few years, there has been a rapid expansion in the application of information
technology to biological data. Particularly the field of immunology has seen great strides in …

It is increasingly clear that an extraordinarily diverse range of clinically important conditions-
including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions …

Motivation Analysis of the T-cell receptor repertoire is rapidly entering the general toolbox
used by researchers interested in cellular immunity. The annotation of T-cell receptors …

Antibody repertoire sequencing (Rep-seq) has been widely used to reveal repertoire
dynamics and to interrogate antibodies of interest at single nucleotide-level resolution …