Cannabidiol: pharmacology and therapeutic targets

SC Britch, S Babalonis, SL Walsh - Psychopharmacology, 2021 - Springer
Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-
treat a myriad of conditions and for their unsubstantiated health benefits. The scientific …

Evidence for use of cannabinoids in mood disorders, anxiety disorders, and PTSD: a systematic review

CN Stanciu, MF Brunette, N Teja… - Psychiatric …, 2021 - Am Psychiatric Assoc
Objective: Two primary compounds of the cannabis plant (Cannabis sativa), delta-9-
tetrahydrocannabinol (THC) and cannabidiol (CBD), differentially and dose-dependently …

Medical cannabis treatment for chronic pain: outcomes and prediction of response

J Aviram, D Pud, T Gershoni… - … Journal of Pain, 2021 - Wiley Online Library
Background Although studied in a few randomized controlled trials, the efficacy of medical
cannabis (MC) for chronic pain remains controversial. Using an alternative approach, this …

Neuropharmacological effects of the main phytocannabinoids: a narrative review

RG Dos Santos, JEC Hallak, JAS Crippa - … and neuropsychiatric disorders, 2021 - Springer
Cannabis can synthetize more than 400 compounds, including terpenes, flavonoids, and
more than 100 phytocannabinoids. The main phytocannabinoids are Δ-9 …

Endocannabinoids, cannabinoids and the regulation of anxiety

GN Petrie, AS Nastase, RJ Aukema, MN Hill - Neuropharmacology, 2021 - Elsevier
Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety
often reported as a primary reason for use. Only recently has the specific role cannabinoids …

Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation

HJ Cindy, HPV Rupasinghe - Research in veterinary science, 2021 - Elsevier
Recent advances in cannabidiol (CBD) use in canines and felines for anxiety management,
pain management, and anti-inflammatory effects were reviewed using a literature search …

Cannabis and cognitive functioning: from acute to residual effects, from randomized controlled trials to prospective designs

J Bourque, S Potvin - Frontiers in psychiatry, 2021 - frontiersin.org
In recent years, several jurisdictions have revised their regulation policy toward both medical
and recreational use of cannabis. These changes have elicited concerns regarding how …

Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis

A O'Neill, R Wilson, G Blest-Hopley… - Psychological …, 2021 - cambridge.org
BackgroundRecent evidence suggests that cannabidiol (CBD), a non-intoxicating ingredient
present in cannabis extract, has an antipsychotic effect in people with established psychosis …

Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic

L Rapin, R Gamaoun, C El Hage, MF Arboleda… - Journal of cannabis …, 2021 - Springer
Background Cannabidiol (CBD) is a primary component in the cannabis plant; however, in
recent years, interest in CBD treatments has outpaced scientific research and regulatory …

The behavioral sequelae of cannabis use in healthy people: a systematic review

M Sorkhou, RH Bedder, TP George - Frontiers in psychiatry, 2021 - frontiersin.org
Background: Cannabis is known to have a broad range of effects on behavior, including
experiencing a “high” and tranquility/relaxation. However, there are several adverse …