The ENIGMA Toolbox: multiscale neural contextualization of multisite neuroimaging datasets

S Larivière, C Paquola, B Park, J Royer, Y Wang… - Nature …, 2021 - nature.com
Through harmonized procedures and by sharing site-specific brain metrics (for example,
cortical thickness) or aggregated statistical maps, ENIGMA has set the stage for large-scale …

Human pluripotent stem-cell-derived models as a missing link in drug discovery and development

X Lin, J Tang, YR Lou - Pharmaceuticals, 2021 - mdpi.com
Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and
human-induced pluripotent stem cells (hiPSCs), have the potential to accelerate the drug …

Characterization of mitochondrial health from human peripheral blood mononuclear cells to cerebral organoids derived from induced pluripotent stem cells

A Duong, A Evstratova, A Sivitilli, JJ Hernandez… - Scientific Reports, 2021 - nature.com
Mitochondrial health plays a crucial role in human brain development and diseases.
However, the evaluation of mitochondrial health in the brain is not incorporated into clinical …

Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics

M Lam, CY Chen, T Ge, Y Xia, DW Hill… - …, 2021 - nature.com
Broad-based cognitive deficits are an enduring and disabling symptom for many patients
with severe mental illness, and these impairments are inadequately addressed by current …

[图书][B] Genetic regulatory variant effects across tissues and individuals

ED Flynn - 2021 - search.proquest.com
Gene expression is regulated by local genetic sequence, and researchers have identified
thousands of common genetic variants in the human population that associate with altered …

[PDF][PDF] Symphony of Matter and Mind. Part Seven. Inner Universe. The Mind as Reality Modeling Process.

S Tregub - 2021 - researchgate.net
INTRODUCTION he Mind is the process of building a model of reality by our brain. Usually
this “inner universe” allows us to adapt to the outside world, but in some cases, it ceases to …

[PDF][PDF] Symphony of Matter and Mind. Part Eight. Dissonances of the Mind. The Physics of Mental Disorders.

S Tregub - 2021 - researchgate.net
INTRODUCTION n psychotherapy and psychiatry, mental illness diagnostics is limited to the
description of symptoms and has nothing to do with assessing the state of the organ that …

[引用][C] Symphony of Matter and Mind. Part Eight. Dissonances of the Mind. Psychopathology as Disturbance of the Brain Technology.

S Tregub - 2021