CaliPro: A Calibration Protocol That Utilizes Parameter Density Estimation to Explore Parameter Space and Calibrate Complex Biological Models

LR Joslyn, DE Kirschner, JJ Linderman - Cellular and molecular …, 2021 - Springer
Introduction Mathematical and computational modeling have a long history of uncovering
mechanisms and making predictions for biological systems. However, to create a model that …

Simulating intervertebral disc cell behaviour within 3D multifactorial environments

L Baumgartner, JJ Reagh… - …, 2021 - academic.oup.com
Motivation Low back pain is responsible for more global disability than any other condition.
Its incidence is closely related to intervertebral disc (IVD) failure, which is likely caused by an …

Agent-based modeling in translational systems biology

G An - … Systems and Computational Biology Approaches to …, 2021 - Springer
Agent-based modeling is an object-oriented, discrete event, population-focused method for
the computational representation of dynamic systems. Agent-based models (ABMs) treat …

[PDF][PDF] Multi-scale agent-based models in immunology. A short

M Pennisi - 2021 - ceur-ws.org
In the drug discovery pipeline, the lack of multi-scale modeling approaches able of taking
into account the observation of an immunological phenomenon from the molecular to the …