Progress in the genetics of uveitis

XF Huang, MA Brown - Genes & Immunity, 2022 - nature.com
Uveitis is the most common form of intraocular inflammatory disease and is a significant
cause of visual impairment worldwide. Aetiologically, uveitis can also be classified into …

Practical significance of biomarkers in axial spondyloarthritis: updates on diagnosis, disease activity, and prognosis

AD Diaconu, A Ceasovschih, V Șorodoc… - International journal of …, 2022 - mdpi.com
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis
by secondary ossification of inflammatory lesions, with progressive disability and a …

Autoimmunity-associated T cell receptors recognize HLA-B* 27-bound peptides

X Yang, LI Garner, IV Zvyagin, MA Paley, EA Komech… - Nature, 2022 - nature.com
Human leucocyte antigen B* 27 (HLA-B* 27) is strongly associated with inflammatory
diseases of the spine and pelvis (for example, ankylosing spondylitis (AS)) and the eye (that …

Genome-wide association study reveals ethnicity-specific SNPs associated with ankylosing spondylitis in the Taiwanese population

CL Ko, WZ Lin, MT Lee, YT Chang, HC Lin… - Journal of Translational …, 2022 - Springer
Background Ankylosing spondylitis (AS) is an autoimmune disease affecting mainly spine
and sacroiliac joints and adjacent soft tissues. Genome-wide association studies (GWASs) …

The genetic backbone of ankylosing spondylitis: how knowledge of genetic susceptibility informs our understanding and management of disease

M Kenyon, S Maguire, A Rueda Pujol, F O'Shea… - Rheumatology …, 2022 - Springer
Ankylosing spondylitis (AS) is a seronegative, chronic inflammatory arthritis with high
genetic burden. A strong association with HLA-B27 has long been established, but to date …

High prevalence of previously undiagnosed axial spondyloarthritis in patients referred with anterior uveitis and chronic back pain: the SpEYE study

RE van Bentum, FD Verbraak, S Wolf… - The Journal of …, 2022 - jrheum.org
Objective. To reduce the diagnostic delay in axial spondyloarthritis (axSpA), guidelines
recommend referring patients with acute anterior uveitis (AAU) and chronic back pain (CBP) …

Factors predicting axial spondyloarthritis among first-degree relatives of probands with ankylosing spondylitis: a family study spanning 35 years

SM Van Der Linden, MA Khan, Z Li… - Annals of the …, 2022 - ard.bmj.com
Objective Factors predicting axial spondyloarthritis (axSpA) among first-degree relatives
(FDRs) of ankylosing spondylitis (AS) patients need to be defined. We investigated the …

Certolizumab Pegol treatment in patients with axial-Spondyloarthritis-associated acute anterior uveitis: a narrative review

IE van der Horst-Bruinsma, PC Robinson… - Rheumatology and …, 2022 - Springer
Background Acute anterior uveitis (AAU) affects up to 40% of patients with axial
spondyloarthritis (axSpA). An effective treatment for patients with axSpA that reduces the risk …

[PDF][PDF] S, orodoc

AD Diaconu, I Ostafie, A Ceasovschih - Int. J. Mol. Sci, 2022 - pdfs.semanticscholar.org
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis
by secondary ossification of inflammatory lesions, with progressive disability and a …

DNA methylation and transcriptional profiles of IRF5 gene in ankylosing spondylitis: A case-control study

M Ni, Y Chen, X Sun, Y Deng, X Wang, T Zhang… - International …, 2022 - Elsevier
Background Interferon regulatory factor 5 (IRF5) plays an important role in the inflammation
and immune responses, but its association with ankylosing spondylitis (AS) is under …