Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …

Transcriptome level expression data connected to the spatial organization of the cells and
molecules would allow a comprehensive understanding of how gene expression is …

Cells do not live in a vacuum, but in a milieu defined by cell–cell communication that can be
measured via emerging high-resolution spatial transcriptomics approaches. However …

Current streamline of precision medicine uses histomorphological and molecular
information to indicate individual phenotypes and genotypes to achieve optimal outcome of …

The placenta is important for fetal development in mammals, and spatial transcriptomic
profiling of placenta helps to resolve its structure and function. In this study, we described the …

Drosophila melanogaster is a powerful, long-standing model for metazoan development and
gene regulation. We profiled chromatin accessibility in almost 1 million and gene expression …

Complex dynamic processes such as development involve the deployment of gene
regulatory pathways that transform the spatial arrangement of cells. Disentangling these …

Under a microscope, mammalian tissues reveal their intricate and elegant architectures. But
if you look at the same tissue after tumour formation, you will see bedlam. Itai Yanai, a …

The spatial organisation of cells defines the biological functions of tissue ecosystems from
development to disease. Recently, an array of technologies have been developed to query …

To reveal the underlying mechanism of the biological function of multicellular systems, it is
important to obtain comprehensive spatial gene expression profiles. Among the emerging …