Metabolic syndrome: updates on pathophysiology and management in 2021

G Fahed, L Aoun, M Bou Zerdan, S Allam… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …

The gut microbiota (microbiome) in cardiovascular disease and its therapeutic regulation

MM Rahman, F Islam, MH -Or-Rashid… - Frontiers in cellular …, 2022 - frontiersin.org
In the last two decades, considerable interest has been shown in understanding the
development of the gut microbiota and its internal and external effects on the intestine, as …

Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases

T Hu, Q Wu, Q Yao, K Jiang, J Yu, Q Tang - Ageing research reviews, 2022 - Elsevier
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, and fatty acid
metabolism has been well studied. Short-chain fatty acids (SCFAs) have been less …

Butyrate to combat obesity and obesity‐associated metabolic disorders: Current status and future implications for therapeutic use

T van Deuren, EE Blaak, EE Canfora - Obesity Reviews, 2022 - Wiley Online Library
Evidence is increasing that disturbances in the gut microbiome may play a significant role in
the etiology of obesity and type 2 diabetes. The short chain fatty acid butyrate, a major end …

Therapeutic effects of butyrate on pediatric obesity: a randomized clinical trial

S Coppola, R Nocerino, L Paparo, G Bedogni… - JAMA Network …, 2022 - jamanetwork.com
Importance The pediatric obesity disease burden imposes the necessity of new effective
strategies. Objective To determine whether oral butyrate supplementation as an adjunct to …

The metabolic role and therapeutic potential of the microbiome

LE Olofsson, F Bäckhed - Endocrine reviews, 2022 - academic.oup.com
We are host to an assembly of microorganisms that vary in structure and function along the
length of the gut and from the lumen to the mucosa. This ecosystem is collectively known as …

[HTML][HTML] Dietary lipids from body to brain

EM Emma, J Amanda - Progress in lipid research, 2022 - Elsevier
Dietary habits have drastically changed over the last decades in Western societies. The
Western diet, rich in saturated fatty acids (SFA), trans fatty acids (TFA), omega-6 …

Protective role of butyrate in obesity and diabetes: New insights

A Mayorga-Ramos, C Barba-Ostria… - Frontiers in …, 2022 - frontiersin.org
Studies in human microbiota dysbiosis have shown that short-chain fatty acids (SCFAs) like
propionate, acetate, and particularly butyrate, positively affect energy homeostasis …

Local and systemic effects of microbiome‐derived metabolites

I Spivak, L Fluhr, E Elinav - EMBO reports, 2022 - embopress.org
Commensal microbes form distinct ecosystems within their mammalian hosts, collectively
termed microbiomes. These indigenous microbial communities broadly expand the genomic …

[HTML][HTML] The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: a systematic review, meta-analysis, and …

P Paul, R Kaul, M Harfouche, M Arabi, Y Al-Najjar… - Pharmacological …, 2022 - Elsevier
Aim/hypothesis The globally escalating diabetes epidemic is responsible for significant
morbidity and mortality. Microbiome-modulating nutraceuticals have been investigated for …