Particle size reduction techniques of pharmaceutical compounds for the enhancement of their dissolution rate and bioavailability
In pharmaceutical research and development, various new chemical entities (NCE) are
found to be poorly water-soluble. Therefore, solubility enhancement, a key factor for higher …
found to be poorly water-soluble. Therefore, solubility enhancement, a key factor for higher …
Spray drying: Inhalable powders for pulmonary gene therapy
Gene therapy holds potential in the treatment of many lung pathologies, as indicated by the
growing number of clinical trials in recent decades. Pulmonary delivery of gene therapies via …
growing number of clinical trials in recent decades. Pulmonary delivery of gene therapies via …
[HTML][HTML] Development of a spray-dried formulation of peptide-DNA nanoparticles into a dry powder for pulmonary delivery using factorial design
Background Gene therapy via pulmonary delivery holds the potential to treat various lung
pathologies. To date, spray drying has been the most promising method to produce …
pathologies. To date, spray drying has been the most promising method to produce …
[HTML][HTML] Macroporous Mannitol Granules Produced by Spray Drying and Sacrificial Templating
M Valentin, D Coibion, B Vertruyen, C Malherbe… - Materials, 2022 - mdpi.com
In pharmaceutical applications, the porous particles of organic compounds can improve the
efficiency of drug delivery, for example into the pulmonary system. We report on the …
efficiency of drug delivery, for example into the pulmonary system. We report on the …
[HTML][HTML] CFD study of dry pulmonary surfactant aerosols deposition in upper 17 generations of human respiratory tract
The efficient generation of high concentrations of fine-particle, pure surfactant aerosols
provides the possibility of new, rapid, and effective treatment modalities for Acute …
provides the possibility of new, rapid, and effective treatment modalities for Acute …
In vivo pharmacokinetic and pharmacodynamic study of co-spray-dried inhalable pirfenidone microparticles in rats
Pirfenidone (PRF) is the first FDA-approved API in the treatment of idiopathic pulmonary
fibrosis (IPF). However, PRF induces serious side effects, such as photophobia and …
fibrosis (IPF). However, PRF induces serious side effects, such as photophobia and …
Aerosol-based Pulmonary Delivery of Therapeutic Molecules from Food Sources: Delivery Mechanism, Research Trends, and the Way Forward
Delivery of food and drug molecules is a challenging field of research with growing interests.
Due to concerns on solubility, stability, and bioavailability, numerous techniques have been …
Due to concerns on solubility, stability, and bioavailability, numerous techniques have been …
Development of Perfluorocarbon Nanoemulsions for Delivery of Therapeutic Nucleic Acids
L Ding - 2022 - digitalcommons.unmc.edu
Local pulmonary administration of therapeutic siRNA represents a promising approach to
the treatment of lung fibrosis, which is currently hampered by inefficient delivery. Pancreatic …
the treatment of lung fibrosis, which is currently hampered by inefficient delivery. Pancreatic …
[PDF][PDF] Application of Phytoglycogen in Dry Powder Inhaler Formulation Design
JY Tse - 2022 - ompu.repo.nii.ac.jp
The ability of pulmonary formulations to reach the alveolar macrophages is investigated.
Taking the antitubercular agent rifampicin (RFP) as an example, the effects on …
Taking the antitubercular agent rifampicin (RFP) as an example, the effects on …
Particle Engineering for Pulmonary Drug Delivery
Aerosolized delivery of drugs to the lungs is the most preferred route of drug administration
for the treatment of respiratory and other ailments. It is employed for the pulmonary delivery …
for the treatment of respiratory and other ailments. It is employed for the pulmonary delivery …