High-risk oncogenic human cytomegalovirus
G Herbein - Viruses, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects between 40% and 95% of the
population worldwide, usually without symptoms. The host immune response keeps the …
population worldwide, usually without symptoms. The host immune response keeps the …
Tumors and cytomegalovirus: an intimate interplay
G Herbein - Viruses, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a herpesvirus that alternates lytic and latent infection,
infecting between 40 and 95% of the population worldwide, usually without symptoms …
infecting between 40 and 95% of the population worldwide, usually without symptoms …
Drug resistance mutations and associated phenotypes detected in clinical trials of maribavir for treatment of cytomegalovirus infection
S Chou, K Song, J Wu, T Bo… - The Journal of infectious …, 2022 - academic.oup.com
Background In separate phase 2 trials, 120 patients received maribavir for cytomegalovirus
(CMV) infection failing conventional therapy (trial 202) and 119 received maribavir for …
(CMV) infection failing conventional therapy (trial 202) and 119 received maribavir for …
Host translesion polymerases are required for viral genome integrity
S Zeltzer, P Longmire, M Svoboda… - Proceedings of the …, 2022 - National Acad Sciences
Human cells encode up to 15 DNA polymerases with specialized functions in chromosomal
DNA synthesis and damage repair. In contrast, complex DNA viruses, such as those of the …
DNA synthesis and damage repair. In contrast, complex DNA viruses, such as those of the …
The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective …
C Berg, MJ Wedemeyer, M Melynis… - PLoS …, 2022 - journals.plos.org
Human cytomegalovirus (HCMV) is a major pathogen in immunocompromised patients. The
UL146 gene exists as 14 diverse genotypes among clinical isolates, which encode 14 …
UL146 gene exists as 14 diverse genotypes among clinical isolates, which encode 14 …
Long range PCR-based deep sequencing for haplotype determination in mixed HCMV infections
N Brait, B Külekçi, I Goerzer - BMC genomics, 2022 - Springer
Background Short read sequencing has been used extensively to decipher the genome
diversity of human cytomegalovirus (HCMV) strains, but falls short to reveal individual …
diversity of human cytomegalovirus (HCMV) strains, but falls short to reveal individual …
Human herpesvirus diversity is altered in HLA class I binding peptides
Herpesviruses are ubiquitous, genetically diverse DNA viruses, with long-term presence in
humans associated with infrequent but significant pathology. Human leukocyte antigen …
humans associated with infrequent but significant pathology. Human leukocyte antigen …
Molecular modelling of the HCMV IL-10 protein isoforms and analysis of their interaction with the human IL-10 receptor
SQ Pantaleão, LMB Camillo, TC Neves, IG Menezes… - Plos one, 2022 - journals.plos.org
The human cytomegalovirus (HCMV) UL111A gene encodes several homologs of the
cellular interleukin 10 (cIL-10). Alternative splicing in the UL111A region produces two …
cellular interleukin 10 (cIL-10). Alternative splicing in the UL111A region produces two …
Haplotype assignment of longitudinal viral deep sequencing data using covariation of variant frequencies
Longitudinal deep sequencing of viruses can provide detailed information about intra-host
evolutionary dynamics including how viruses interact with and transmit between hosts. Many …
evolutionary dynamics including how viruses interact with and transmit between hosts. Many …
Pathogenesis of wild-type-like rhesus cytomegalovirus strains following oral exposure of immune-competent rhesus macaques
Rhesus cytomegalovirus (RhCMV) infection of rhesus macaques (Macaca mulatta) is a
valuable nonhuman primate model of human CMV (HCMV) persistence and pathogenesis …
valuable nonhuman primate model of human CMV (HCMV) persistence and pathogenesis …