Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is activated in chronic inflammatory states,
eg, in the aging process and age-related diseases. IDO1 enzyme catabolizes L-tryptophan …

Inflammaging is a term used to describe the tight relationship between low-grade chronic
inflammation and aging that occurs during physiological aging in the absence of evident …

The hypothalamus is a critical brain region for the regulation of energy homeostasis. Over
the years, studies on energy metabolism primarily focused on the neuronal component of …

Microgravity exposure causes several physiological and psychosocial alterations that
challenge astronauts' health during space flight. Notably, many of these changes are mostly …

Ageing represents a major risk factor for many pathologies that limit human lifespan,
including cardiovascular diseases. Biological ageing is a good biomarker to assess early …

Inflammaging is a low-grade inflammatory state generated by the aging process that can
contribute to frailty and age-related diseases in the elderly. However, it can have distinct …

Aging is associated with reduced appetite as well as a slight increase in pro-inflammatory
status, which both might contribute to the development of malnutrition. We aimed to evaluate …

Aging and age-related diseases represent hot topics of current research. Progressive
damage in morphology and function of cells and tissue characterizes the normal process of …

Aging is a natural process of extinction of the body and the main aspect that determines the
life expectancy for individuals who have survived to the post-reproductive period. The …