[HTML][HTML] Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and …
Asthma is a chronic and heterogeneous respiratory disease with many risk factors that
typically originate during early childhood. A complex interplay between environmental …
typically originate during early childhood. A complex interplay between environmental …
Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?
S Kittel-Schneider, G Arteaga-Henriquez… - Neuroscience & …, 2022 - Elsevier
Several non-mental diseases seem to be associated with an increased risk of ADHD and
ADHD seems to be associated with increased risk for non-mental diseases. The underlying …
ADHD seems to be associated with increased risk for non-mental diseases. The underlying …
An atlas of genetic correlations and genetically informed associations linking psychiatric and immune-related phenotypes
Importance Certain psychiatric and immune-related disorders are reciprocal risk factors.
However, the nature of these associations is unclear. Objective To characterize the …
However, the nature of these associations is unclear. Objective To characterize the …
[PDF][PDF] Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity
Asthma is a complex disease that varies widely in prevalence across populations. The
extent to which genetic variation contributes to these disparities is unclear, as the genetics …
extent to which genetic variation contributes to these disparities is unclear, as the genetics …
Associations between pregnancy-related predisposing factors for offspring neurodevelopmental conditions and parental genetic liability to attention-deficit …
Importance Several maternal exposures during pregnancy are considered predisposing
factors for offspring neurodevelopmental conditions. However, many of these exposures …
factors for offspring neurodevelopmental conditions. However, many of these exposures …
[HTML][HTML] Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma
Obesity and asthma are both common diseases with high population burden worldwide.
Recent genetic association studies have shown that obesity is associated with asthma in …
Recent genetic association studies have shown that obesity is associated with asthma in …
[HTML][HTML] Multiancestral polygenic risk score for pediatric asthma
Background Asthma is the most common chronic condition in children and the third leading
cause of hospitalization in pediatrics. The genome-wide association study catalog reports …
cause of hospitalization in pediatrics. The genome-wide association study catalog reports …
One genome, many cell states: epigenetic control of innate immunity
I Fraschilla, H Amatullah, KL Jeffrey - Current opinion in immunology, 2022 - Elsevier
Highlights•Chromatin dynamics regulate pattern, timing and magnitude of gene
expression.•Signal transduction downstream of TLR4 regulate histones for inducible gene …
expression.•Signal transduction downstream of TLR4 regulate histones for inducible gene …
[HTML][HTML] Exploring genetic association of insomnia with allergic disease and asthma: a bidirectional Mendelian randomization study
R Li, Y Chen, A Zhao, L Huang, Z Long, W Kang… - Respiratory …, 2022 - Springer
Background Insomnia is highly prevalent among patients with allergic disease and asthma;
however, few studies have investigated their causal relationship. We aim to explore the …
however, few studies have investigated their causal relationship. We aim to explore the …
Paediatric asthma and non‐allergic comorbidities: A review of current risk and proposed mechanisms
It is increasingly recognized that children with asthma are at a higher risk of other non‐
allergic concurrent diseases than the non‐asthma population. A plethora of recent research …
allergic concurrent diseases than the non‐asthma population. A plethora of recent research …