ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies

AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Host genetic basis of COVID-19: from methodologies to genes

K Zguro, C Fallerini, F Fava, S Furini… - European Journal of …, 2022 - nature.com
The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) is having a massive impact on public health, societies, and economies …

Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample

MS Naslavsky, CK Suemoto, LA Brito, MO Scliar… - Molecular …, 2022 - nature.com
Dementia is more prevalent in Blacks than in Whites, likely due to a combination of
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …

Nutrigenetics, omega-3 and plasma lipids/lipoproteins/apolipoproteins with evidence evaluation using the GRADE approach: a systematic review

J Keathley, V Garneau, V Marcil, DM Mutch… - BMJ open, 2022 - bmjopen.bmj.com
Objectives Despite the uptake of nutrigenetic testing through direct-to-consumer services
and healthcare professionals, systematic reviews determining scientific validity are limited in …

COVID-19 vaccine uptake among family caregivers of people with dementia: the role of attitudes toward vaccination, perceived social support and personality traits

F Bruno, A Malvaso, F Chiesi, V Laganà… - Frontiers in …, 2022 - frontiersin.org
People with dementia have an increased risk of contracting severe forms of COVID-19.
Although in worldwide vaccination programs priority has been given to older people, having …

Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism

I Espinosa-Salinas, G Colmenarejo… - Scientific Reports, 2022 - nature.com
The pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public
health emergency. Increasing understanding about predisposing factors to infection and …

A re-evaluation of candidate gene studies for well-being in light of genome-wide evidence

MP van de Weijer, DHM Pelt, LP de Vries… - Journal of Happiness …, 2022 - Springer
Ever since twin-family studies found that a substantial amount (±40%) of the variation in well-
being can be explained by genetic variation, several candidate genes have been proposed …

Brain Structural Mapping of Multi-factorial Aging Mechanism Using 35,035 UK Biobank Subjects

J Chen, T Li, B Zhao, H Chen, C Yuan, GA Gardern… - medRxiv, 2022 - medrxiv.org
Mounting evidence shows that the complex interaction between genes and environmental
exposures is one of the major reasons for the diverse trajectories of micro-and macro …

Apolipoprotein E*Ɛ2 carriers exhibit high aspirin-treated platelet reactivity and low cardiovascular risk during long-term aspirin treatment

XL Li, Q Wang, GD Jia, HJ Yin, YH Wang, C Hu… - Age and …, 2022 - academic.oup.com
Abstract Objective Apolipoprotein E (APOE) loci, including rs429358 (Ɛ4) and rs7412 (Ɛ2),
are involved in cardiovascular (CV) health. However, their effect on the CV-protective effect …

[HTML][HTML] Demencia como factor pronóstico de la mortalidad por covid-19

PE Bombón-Albán - Acta Neurológica Colombiana, 2022 - scielo.org.co
El riesgo de exposición a covid-19 es importante en las personas mayores con demencia,
muy expuestos en el contexto de centros de larga estancia, hospitalizaciones frecuentes y …