[HTML][HTML] m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
[HTML][HTML] Insights into N6-methyladenosine and programmed cell death in cancer
L Liu, H Li, D Hu, Y Wang, W Shao, J Zhong, S Yang… - Molecular cancer, 2022 - Springer
Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA
modification in eukaryotes, has gained increasing attention and become a hot research topic …
modification in eukaryotes, has gained increasing attention and become a hot research topic …
[HTML][HTML] Role of m6A writers, erasers and readers in cancer
Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …
human RNAs. In recent years, an increasing number of studies have suggested that m6A …
JNK Signaling Promotes Bladder Cancer Immune Escape by Regulating METTL3-Mediated m6A Modification of PD-L1 mRNA
Z Ni, P Sun, J Zheng, M Wu, C Yang, M Cheng, M Yin… - Cancer research, 2022 - AACR
The RNA N6-methyladenosine (m6A) writer methyltransferase-like 3 (METTL3) is
upregulated in many types of cancer and promotes cancer progression by increasing …
upregulated in many types of cancer and promotes cancer progression by increasing …
[HTML][HTML] RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner
S Sun, T Gao, B Pang, X Su, C Guo, R Zhang… - Cell death & …, 2022 - nature.com
Ferroptosis is a form of cell death characterized by lipid peroxidation. Previous studies have
reported that knockout of NF-κB activating protein (NKAP), an RNA-binding protein …
reported that knockout of NF-κB activating protein (NKAP), an RNA-binding protein …
[HTML][HTML] Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …
Epigenetic modification refers to heritable changes in the genetic material without any …
[HTML][HTML] METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability
H Li, C Wang, L Lan, L Yan, W Li, I Evans… - Cellular and Molecular …, 2022 - Springer
Oxaliplatin is the first-line regime for advanced gastric cancer treatment, while its resistance
is a major problem that leads to the failure of clinical treatments. Tumor cell heterogeneity …
is a major problem that leads to the failure of clinical treatments. Tumor cell heterogeneity …
[HTML][HTML] METTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4
M Li, J Ye, Y Xia, M Li, G Li, X Hu, X Su, D Wang… - Leukemia, 2022 - nature.com
Chemoresistant leukemia relapse is one of the most common causes of death for acute
myeloid leukemia (AML) patients and the homing/engraftment in bone marrow (BM) are …
myeloid leukemia (AML) patients and the homing/engraftment in bone marrow (BM) are …
[HTML][HTML] ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1
W Sun, Y Li, D Ma, Y Liu, Q Xu, D Cheng, G Li… - Cellular & molecular …, 2022 - Springer
Abstract Background N 6-methyladenosine (m6A) is the most common and abundant
internal modification of RNA. Its critical functions in multiple physiological and pathological …
internal modification of RNA. Its critical functions in multiple physiological and pathological …
Roles and drug development of METTL3 (methyltransferase-like 3) in anti-tumor therapy
P Xu, R Ge - European journal of medicinal chemistry, 2022 - Elsevier
Methyltransferase complex, such as METTL3/METTL14/WTP, catalyze N 6-methyladenosine
(m 6 A), which is the most abundant mRNA modification in mammals. Besides acting as am …
(m 6 A), which is the most abundant mRNA modification in mammals. Besides acting as am …