Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

The goal of this study was to test the role cellular senescence plays in the increased
inflammation, chronic liver disease, and hepatocellular carcinoma seen in mice null for …

Cell death is an essential process that plays a vital role in restoring and maintaining skin
homeostasis. It supports recovery from acute injury and infection and regulates barrier …

Damage-associated molecular patterns (DAMPs) are molecules within living cells that are
released when cell membranes are ruptured. Although DAMPs have physiological functions …

Background Traumatic brain injury (TBI) and spinal cord injury (SCI) are capable of causing
severe sensory, motor and autonomic nervous system dysfunctions. However, effective …

Plant intracellular immune receptors known as NLR (nucleotide‐binding leucine‐rich
repeat) proteins confer immunity and cause cell death. Plant NLR proteins that directly or …

The understanding of the pathogenesis of renal cell carcinoma led to the development of
targeted therapies, which dramatically changed the overall survival rate. Nonetheless …

Despite currently available therapies, cardiovascular diseases (CVD) are among the leading
causes of death globally. Biological sex is a critical determinant of the occurrence …

Necroptosis is a form of regulated cell death that can occur downstream of several immune
pathways. While previous studies have shown that dysregulated necroptosis can lead to …