The kynurenine pathway and kynurenine 3-monooxygenase inhibitors

TD Hughes, OF Güner, EC Iradukunda, RS Phillips… - Molecules, 2022 - mdpi.com
Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in
generating cellular energy and catabolizing tryptophan. Under inflammatory conditions …

[HTML][HTML] Supramolecular microgels/microgel scaffolds for tissue repair and regeneration

K Wang, Z Wang, H Hu, C Gao - Supramolecular Materials, 2022 - Elsevier
Biomedical microgels are a novel type of materials with promising perspectives for repair
and regeneration of multi-types of tissues and organs due to their highly hydrated nature …

Receptor-independent fluid-phase macropinocytosis promotes arterial foam cell formation and atherosclerosis

HP Lin, B Singla, WM Ahn, P Ghoshal… - Science translational …, 2022 - science.org
Accumulation of lipid-laden foam cells in the arterial wall plays a central role in
atherosclerotic lesion development, plaque progression, and late-stage complications of …

Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke

E Sideris, S Kioulaphides, KL Wilson, A Yu… - Advanced …, 2022 - Wiley Online Library
Increasing numbers of individuals live with stroke related disabilities. Following stroke,
highly reactive astrocytes and pro‐inflammatory microglia can release cytokines and lead to …

Causes, circumstances, and potential preventability of cardiac arrest in the young: insights from a state-wide clinical and forensic registry

ED Paratz, A van Heusden, D Zentner, N Morgan… - Europace, 2022 - academic.oup.com
Aims The causes, circumstances, and preventability of young sudden cardiac arrest remain
uncertain. Methods and results A prospective state-wide multi-source registry identified all …

Theta–gamma coupling as a cortical biomarker of brain–computer interface-mediated motor recovery in chronic stroke

N Rustamov, J Humphries, A Carter… - Brain …, 2022 - academic.oup.com
Chronic stroke patients with upper-limb motor disabilities are now beginning to see
treatment options that were not previously available. To date, the two options recently …

[HTML][HTML] Stroke epidemiology in southern Brazil: Investigating the relationship between stroke severity, hospitalization costs, and health-related quality of life

DM Tereza, GM Baldasso, RS Paes… - Anais da Academia …, 2022 - SciELO Brasil
We aimed with the present study to fill the gap on the performance and safety of stroke
management and the costs related to hospitalizations, the relevant comorbidities associated …

Chronic pediatric diseases and risk for reading difficulties: a narrative review with recommendations

D Perazzo, R Moore, NA Kasparian, M Rodts… - Pediatric …, 2022 - nature.com
Literacy is a major social determinant of health, rooted in skills that develop during early
childhood. Children arriving at kindergarten unprepared to learn to read are more likely to …

Sestrin2 ablation attenuates the exercise‐induced browning of white adipose tissue in C57BL/6J mice

L Wang, X Liu, S Liu, Y Niu, L Fu - Acta Physiologica, 2022 - Wiley Online Library
Aim With exercise, white adipose tissues (WAT) are readily convertible to a “brown‐like”
state, altering from lipid‐storing to energy‐catabolizing function, which counteracts obesity …

Racial disparities in cardiovascular risk and cardiovascular care in women

RM Brown, S Tamazi, CR Weinberg, A Dwivedi… - Current cardiology …, 2022 - Springer
Abstract Purpose of Review Research on sex and gender aspects cardiovascular disease
has contributed to a reduction in cardiovascular mortality in women. However …