Engineering in vitro immune-competent tissue models for testing and evaluation of therapeutics

JH Hammel, JM Zatorski, SR Cook… - Advanced drug delivery …, 2022 - Elsevier
Advances in 3D cell culture, microscale fluidic control, and cellular analysis have enabled
the development of more physiologically-relevant engineered models of human organs with …

[HTML][HTML] In vitro, in vivo, and in silico models of lymphangiogenesis in solid malignancies

S Bekisz, L Baudin, F Buntinx, A Noël, L Geris - Cancers, 2022 - mdpi.com
Simple Summary Lymphangiogenesis is the formation of new lymphatic vessels in
physiological conditions but has also been found to be associated with pathologies. For …

Lymph-derived chemokines direct early neutrophil infiltration in the lymph nodes upon Staphylococcus aureus skin infection

J Xue, Y Lin, D Oo, J Zhang… - Proceedings of the …, 2022 - National Acad Sciences
A large number of neutrophils infiltrate the lymph node (LN) within 4 h after Staphylococcus
aureus skin infection (4 h postinfection [hpi]) and prevent systemic S. aureus dissemination …

[HTML][HTML] A mathematical description of the flow in a spherical lymph node

G Giantesio, A Girelli, A Musesti - Bulletin of Mathematical Biology, 2022 - Springer
The motion of the lymph has a very important role in the immune system, and it is influenced
by the porosity of the lymph nodes: more than 90% takes the peripheral path without …

[HTML][HTML] Three-dimensional analyses of vascular network morphology in a murine lymph node by X-ray phase-contrast tomography with a 2D Talbot array

FL Schwarzenberg, P Schütz, JU Hammel… - Frontiers in …, 2022 - frontiersin.org
With growing molecular evidence for correlations between spatial arrangement of blood
vasculature and fundamental immunological functions, carried out in distinct compartments …

[HTML][HTML] Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system

Y Shou, SC Johnson, YJ Quek, X Li, A Tay - Materials Today Bio, 2022 - Elsevier
The lymph node (LN) is a vital organ of the lymphatic and immune system that enables
timely detection, response, and clearance of harmful substances from the body. Each LN …

[HTML][HTML] Computational modeling of lymph filtration and absorption in the lymph node by boundary integral equations

A Setukha, R Tretiakova - Algorithms, 2022 - mdpi.com
We develop a numerical method for solving three-dimensional problems of fluid filtration and
absorption in a piecewise homogeneous medium by means of boundary integral equations …

[HTML][HTML] Phenotyping polarization dynamics of immune cells using a lipid droplet-cell pairing microfluidic platform

L Pinon, N Ruyssen, J Pineau, O Mesdjian… - Cell Reports …, 2022 - cell.com
The immune synapse is the tight contact zone between a lymphocyte and a cell presenting
its cognate antigen. This structure serves as a signaling platform and entails a polarization of …

Cellular mechanisms of cancer collective invasion and response to treatments

DL Pagès - 2022 - theses.hal.science
Metastases cause most cancer deaths and despite the great advances of the last decades,
finding an efficient therapy for each patient remains a challenge. Therefore, deciphering the …

Modeling Mechanical Feedback Mechanisms in a Multiscale Sliding Filament Model of Lymphatic Muscle Pumping

PY Xie, CJ Morris, C Bertram, D Zaweija, JE Moore Jr - bioRxiv, 2022 - biorxiv.org
The lymphatic system maintains bodily fluid balance by returning interstitial fluid to the
venous system. Flow can occur through a combination of extrinsic pumping, due to forces …