FDA-approved kinase inhibitors in preclinical and clinical trials for neurological disorders

A Lui, J Vanleuven, D Perekopskiy, D Liu, D Xu… - Pharmaceuticals, 2022 - mdpi.com
Cancers and neurological disorders are two major types of diseases. We previously
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …

Mouse models for unravelling immunology of blood stage malaria

AC Olatunde, DH Cornwall, M Roedel, TJ Lamb - Vaccines, 2022 - mdpi.com
Malaria comprises a spectrum of disease syndromes and the immune system is a major
participant in malarial disease. This is particularly true in relation to the immune responses …

Sulfadiazine plus pyrimethamine therapy reversed multiple behavioral and neurocognitive changes in long-term chronic toxoplasmosis by reducing brain cyst load …

BL Castaño, AA Silva, LL Hernandez-Velasco… - Frontiers in …, 2022 - frontiersin.org
Toxoplasma gondii infects one-third of the world population. For decades, it has been
considered a silent lifelong infection. However, chronically T. gondii-infected persons may …

Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria

P Rosa-Gonçalves, LP de Sousa, AB Maia… - Frontiers in …, 2022 - frontiersin.org
Data recently reported by our group indicate that stimulation with a pool of immunogens
capable of eliciting type 2 immune responses can restore the cognitive and behavioral …

Comparative analysis of host metabolic alterations in murine malaria models with uncomplicated or severe malaria

A Das, W Sahu, DK Ojha, KS Reddy… - Journal of Proteome …, 2022 - ACS Publications
Malaria varies in severity, with complications ranging from uncomplicated to severe malaria.
Severe malaria could be attributed to peripheral hyperparasitemia or cerebral malaria. The …

Transcellular blood–brain barrier disruption in malaria-induced reversible brain edema

J Jin, MA Ba, CH Wai, S Mohanty… - Life science …, 2022 - life-science-alliance.org
Brain swelling occurs in cerebral malaria (CM) and may either reverse or result in fatal
outcome. It is currently unknown how brain swelling in CM reverses, as brain swelling at the …

Lymphotoxin-α Orchestrate Hypoxia and Immune factors to Induce Experimental Cerebral Malaria: Inhibition Mitigates Pathogenesis, Neurodegeneration, and …

P Eeka, PB Phanithi - Journal of Molecular Neuroscience, 2022 - Springer
Knockdown studies have shown lymphotoxin-α (Lt-α) as a critical molecule for Experimental
cerebral malaria (ECM) pathogenesis. We investigated the role of lymphotoxin-α in …

Listeria monocytogenes Inoculation Impedes the Development of Brain Pathology in Experimental Cerebral Malaria by Inhibition of Parasitemia

J Yang, X Han, KN Gao, ZM Qi - ACS Infectious Diseases, 2022 - ACS Publications
Cerebral malaria (CM) is a serious central nervous system dysfunction caused by
Plasmodium falciparum infection. In this study, we investigated the effect of Listeria …

Impact of Interleukin-34 on the Promotion of Bone Osteolysis and Neuroinflammation in Experimental Models of Alzheimer'S Disease

A Ho - 2022 - nsuworks.nova.edu
Alzheimer's disease (AD) is a growing health concern and is the most common type of
dementia worldwide. Emerging evidence indicates that aggregated amyloid-beta (Aβ) …

T cell response to an MHC-II restricted epitope of rodent malaria

MH Enders - 2022 - bonndoc.ulb.uni-bonn.de
Malaria is caused by different Plasmodium species that can infect a variety of animals
including humans and rodents. The life cycle of these parasites is complex and includes a …