Defects in DNA repair pathways are emerging hallmarks of cancer. Accurate DNA repairs
and replications are essential for genomic stability. Cancer cells require residual DNA repair …

Simple Summary Hypoxia (reduced oxygen availability) is common in the majority of
tumours, including head and neck cancer, and it occurs due to an imbalance between …

The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR)
during their course of treatment, yet the efficacy of these therapies is tempered by DNA …

Abstract Analysis of DNA double-strand breaks (DSBs) is an important novel tool to estimate
the biological effects of ionizing radiation. Despite the large number of developed methods …

Purpose. Poly (ADP‐ribose) polymerase 1 (PARP1) is necessary for single‐strand break
(SSB) repair by sensing DNA breaks and facilitating DNA repair through poly ADP …

Chemoresistance remains the primary challenge of clinical treatment of gastric cancer (GC),
making the biomarkers of chemoresistance crucial for treatment decision. Our previous study …

The breast cancer type 1 susceptibility protein (BRCA1) and its partner–the BRCA1-
associated RING domain protein 1 (BARD1)–are key players in a plethora of fundamental …

Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and has the
second highest mortality rate globally. Thanks to the advent of next-generation sequencing …

According to current guidelines, the current treatment for locally advanced rectal cancer is
neoadjuvant therapy, followed by a total mesorectal excision. However, radiosensitivity …

Objective. RAD51 homolog 1 (RAD51) plays significant roles in DNA damage repair and
apoptosis. These pathways are tightly associated with tumor initiation and progression. To …